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Gene expression profile in response to SDH2 deletion during filament formation in both Spider medium and Spider medium supplemented with 100mM glucose

ABSTRACT: Transcriptional profiling of Candida albicans comparing SDH2 deletion mutant cells with the wild-type cells in both Spider medium and Spider medium supplemented with 100mM glucose

ORGANISM(S): Candida albicans

PROVIDER: GSE50155 | GEO | 2016/08/23

SECONDARY ACCESSION(S): PRJNA216918

REPOSITORIES: GEO

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Gene expression profile in response to SDH2 deletion during filament formation in both Spider medium and Spider medium supplemented with 100mM glucose

Project description:Transcriptional profiling of Candida albicans comparing SDH2 deletion mutant cells with the wild-type cells in both Spider medium and Spider medium supplemented with 100mM glucose The SDH2 deletion mutant sdh2Î/Î and the wild-type strain SC5314 were used to perform the microarray experiments. Two-condition experiments: sdh2Î/Î vs SC5314 in Spider midium and sdh2Î/Î vs SC5314 in Spider midium supplemented with 100mM glucose. Biological replicates: 3 SDH2 deletion mutant sdh2Î/Î samples (test group), 3 wild-type strain SC5314 samples (control group), independently grown and harvested. One replicate per array.

2016-08-23 | E-GEOD-50155 | biostudies-arrayexpress

Gene expression profile in response to NGG1 deletion during filament formation in Spider medium

Project description:Transcriptional profiling of Candida albicans comparing NGG1 deletion mutant cells with the wild-type cells in Spider medium

2018-01-31 | GSE93200 | GEO

Disclosing the venom peptidome of the Amazonian spider Acanthoscurria juruenicola

Project description:Acanthoscurria juruenicola is an Amazonian tarantula spider described for the first time a century ago. Specimens of both genders are similar in size and in most morphological aspects, but ecological behavior and their venom composition remained unknown to date. Here we present the peptidomics characterization of the spider venom by a combination of mass spectrometric analysis of both native and digested peptides, venom gland transcriptomics and bioinformatics. A total of 367 native features were observed in the venom peptidome. Seventeen cysteine-rich peptides were simultaneously observed in the transcriptome and in the mass spectrometric experiments, from which fourteen were completely sequenced in the mature forms. The mature peptides have 3-5 disulfide bonds and cover the 3.7-8.6 kDa mass range. Moreover, in vivo paralytic activities of the whole venom were observed in crickets. In silico analysis indicated that all mature peptides are potentially antimicrobial and two may be potential anticancer agents. The antimicrobial activity was experimentally confirmed for the peptide Ap1a against Micrococcus luteus, Pseudomonas aeruginosa and Candida albicans.

2022-10-20 | PXD013149 | Pride

Differential gene expression in the grf10Δ mutant of Candida albicans in high copper containing growth medium

Project description:To identify genes in that are misregulated in the grf10Δ mutant of Candida albicans in response to growth in high copper, we compared expression patterns of the grf10-null mutant relative to the isogenic WT in YPD medium supplemented with and without 12 mM CuSO4.

2023-03-20 | GSE223217 | GEO

Candida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes

Project description:Transcriptional profiling of Candida albicans after 3 h phagocytosis by vehicle DMSO-treated macrophages (intact, expanding phagosomes) or calcium chelator BAPTA-AM-treated macrophages (inhibits lysosomal repair of expanding phagosomes, leading to phagosome rupture) to determine the effect of preventing phagosome expansion on C. albicans gene expression after phagocytosis by macrophages. Cultivation of Candida only for 3 h in DMEM-FBS cell culture medium or YPD complex medium as non-phagocytosis control conditions.

2020-10-05 | GSE147207 | GEO

Transcription profiling of Candida albicans in response to a sudden availability of glucose in the extracellular medium, having previously been grown on a non-fermentable carbon source

Project description:We investigated how Candida albicans adapts its transcriptional pattern to a sudden availability of glucose in the extracellular medium, having previously grown on a non-fermentable carbon source.

2008-06-01 | E-MEXP-1151 | biostudies-arrayexpress

RNA sequencing data of Candida albicans white, opaque, and white engineered cells under mating conditions

Project description:C. albicans white, opaque and white engineered cells were incubated on Spider medium for 8 hours. Crosses were between a and alpha cells of each phenotype, and a white cells alone or a opaque cells alone were also incubated as controls. White cells are no

2017-12-20 | GSE103674 | GEO

spider microbiomes

Project description:spider microbiomes

| PRJNA526944 | ENA

Candida albicans Microarray studies: CAP2 (Wild type) vs. cap2D (Homozygous null mutant)

Project description:Transcriptome profiling to identify Cap2/Hap43 regulons in the human fungal pathogen Candida albicans: Wild type vs. cap2D grown in iron-depleted medium

2011-05-25 | GSE28429 | GEO

Microarray analyses of C. albicans sak1 deletion mutant in complex liquid medium (YPD)

Project description:Sak1 (orf19.3840) of Candida albicans was found to be a kinase which phosphorylates and thereby activates Snf1, a highly conserved regulator of nutrient stress responses. Accordingly, a sak1 deletion mutant failed to grow on many alternative (i.e., non-glucose) carbon sources, but also showed a filamentation defect upon growth under glucose limitation and exhibited reduced virulence. To better define the effects of Sak1 on C. albicans metabolic adaptations, these transcriptional analyses were performed in complex medium, using a sak1 deletion mutant in comparison to the wild type.

2017-05-02 | E-MTAB-5415 | biostudies-arrayexpress

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