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Pancreatic cancer cell exosomal microRNA as diagnostic marker

ABSTRACT: Pancreatic cancer has a dismal prognosis partly due to late diagnosis, where a reliable non-invasive diagnosis is urgently wanted. We here explored, whether serum-derived PaCa exosomes may provide a diagnostic means and microRNA may be advantageous. Exosomes were collected from the serum of 133 patients with pancreatic cancer, 22 patients with non-malignant pancreatic tumors, 25 patients with chronic pancreatitis and 20 healthy donors. Exosomes were isolated by ultracentrifugation and used qRT-PCR for miRNA quantification and miRCURY LNA microRNA Array for miRNA analysis.

ORGANISM(S): Merkel cell polyomavirus Mus musculus Rattus norvegicus Human alphaherpesvirus 2 Cytomegalovirus Lymphocryptovirus JC polyomavirus Betapolyomavirus macacae Murid gammaherpesvirus 4 Homo sapiens Human immunodeficiency virus 1 Human betaherpesvirus 5 Rhadinovirus Human alphaherpesvirus 1 Betapolyomavirus hominis

PROVIDER: GSE50632 | GEO | 2014/12/01

SECONDARY ACCESSION(S): PRJNA218118

REPOSITORIES: GEO

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