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Nascent strand with BrdU or lambda exonuclease

ABSTRACT: Nascent strand were purified with either the BrdU or the lambda exonuclease methods from culture human basophilic erythroblasts and sequenced/

ORGANISM(S): Homo sapiens

PROVIDER: GSE50976 | GEO | 2014/05/01

SECONDARY ACCESSION(S): PRJNA219472

REPOSITORIES: GEO

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Nascent strand with BrdU or lambda exonuclease

Project description:Nascent strand were purified with either the BrdU or the lambda exonuclease methods from culture human basophilic erythroblasts and sequenced/ Two methods were compared to isolated the Nascent strand, lambda exonuclease digestion or immunoprecipitation after pulse labelling with BrdU The following files were generated by combining round 1 and 2 sample files; FNY01_2_2_Ery_NS_BrdU_macs_summits.bed FNY01_2_2_Ery_NS_BrdU_macs_peaks.bed FNY01_2_2_Ery_NS_lexo_macs_peaks.bed FNY01_2_2_Ery_NS_lexo_macs_summits.bed

2014-05-01 | E-GEOD-50976 | biostudies-arrayexpress

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Project description:Nascent strand were purified with the BrdU methods from culture human basophilic erythroblasts and sequenced.

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Allele-Specific Analysis of DNA Replication Origins in Mammalian Cells

Project description:Nascent strand were purified with the BrdU methods from culture human basophilic erythroblasts and sequenced. An allele-specific analysis of origin of replication efficiency was performed by taking advantage of the phased genome sequence of an individual

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Homo sapiens

Project description:Nascent strand with BrdU or lambda exonuclease

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Project description:We performed whole genome analysis of the DNA binding of five Saccharomyces cerevisiae transcription factors involved in lipid biosynthesis, Ino2, Ino4, Hap1, Oaf1 and Pip2, in response to four different environmental conditions. Using chromatin immunoprecipitation with lambda exonuclease digestion (ChIP-exo) we discovered a large number of so-far unidentified targets with nucleotide resolution. Based on the newly identified targets we document expanded functions for all five transcription factors, e.g. glutamate biosynthesis as a target of Oaf1 and Pip2. Moreover, condition-dependent binding of transcription factors in response to cell metabolic state, e.g. differential binding of Ino2 between fermentative and respiratory metabolic conditions was clearly suggested. Using our data we build a comprehensive transcriptional regulatory network for lipid metabolism in yeast.

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Global delay in nascent strand DNA methylation

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