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Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age

ABSTRACT: Epigenome-wide association study of age at menarche in a group of 329 women from the EPIC-Italy cohort.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51057 | GEO | 2013/09/21

SECONDARY ACCESSION(S): PRJNA219952

REPOSITORIES: GEO

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Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age

Project description:Epigenome-wide association study of age at menarche in a group of 329 women from the EPIC-Italy cohort. A total of 329 samples from the EPIC-Italy cohort were analyzed. No replicates are available.

2013-09-21 | E-GEOD-51057 | biostudies-arrayexpress

EPIC-Italy at HuGeF

Project description:This Series contains data from 845 participants (188 men and 657 women) in the EPIC-Italy cohort that was produced at the Human Genetics Foundation (HuGeF) in Turin, Italy. At the last follow-up (2010), 424 participants remained cancer-free, 235 had developed primary breast cancer, 166 had developed primary colorectal cancer, and 20 had developed other primary cancers. Anthropometric measurements, and dietary and lifestyle information obtained by questionnaire are also available. A total of 845 samples from the EPIC-Italy cohort were analyzed.

2013-09-20 | E-GEOD-51032 | biostudies-arrayexpress

EPIC-Italy at HuGeF

2013-09-20 | GSE51032 | GEO

Methylome analysis and epigenetic changes associated with menarcheal age.

Project description: Not available

| S-EPMC3835804 | biostudies-literature

Homo sapiens

Project description:EPIC-Italy at HuGeF

| PRJNA219744 | ENA

High-resolution analyses of human sperm dynamic methylome reveals thousands of novel age-related epigenetic alterations

Project description:Age-dependent modifications of the germ cells epigenome remain poorly understood. Our objective was to assess the DNA methylation profile of human spermatozoa during aging. A cohort study was designed to investigate the effects of age and fertility status on sperm DNA methylation.

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The acute effects of chemotherapy and radiotherapy on peripheral blood epigenetic age in early stage breast cancer patients

Project description:Genome wide DNA methylation profiling of human blood samples. The Illumina Infinium EPIC DNA methylation Beadchip was used to obtain DNA methylation profiles Survival has increased in early stage breast cancer (BC), and the late effects of cancer treatment can persist for decades. The molecular mechanisms underlying acceleration of age-related diseases after chemotherapy and radiotherapy are poorly understood. We examined epigenetic changes in peripheral blood in early stage BC patients undergoing either adjuvant radiotherapy, or adjuvant chemotherapy and radiotherapy. DNA methylation experiments were performed on peripheral blood samples from women collected prior to and following completion of adjuvant therapy. Methylation profiles were used to estimate three measures of epigenetic age acceleration - intrinsic, extrinsic, and phenotypic - as well as estimated cell counts.

2020-06-23 | GSE140038 | GEO

Epigenetic Signature of Chronic Low Back Pain in Human T Cells

Project description:We performed genome-wide DNA methylation analysis of 850,000 CpG sites in women and men with chronic Low Back Pain (LBP) and pain free-controls. T cells were isolated (Discovery Cohort, n=32) and used to identify differentially methylated CpG sites, and gene ontologies and molecular pathways were identified.T cells were isolated (Discovery Cohort, n=32) and used to identify differentially methylated CpG sites, and gene ontologies and molecular pathways were identified. A polygenic DNA methylation score for LBP was generated in both women and men. Validation was performed in an independent cohort (Validation Cohort, n=63) of chronic LBP and healthy controls. Analysis with the Discovery Cohort revealed a total of 2,496 and 419 differentially methylated CpGs in women and men, respectively. The majority of these sites were hypo-methylated in women and enriched in genes with functions in the extracellular matrix, the immune system (i.e. cytokines) or in epigenetic processes. In men, we identified a unique chronic LBP DNA methylation signature characterized by significant enrichment for genes from the major histocompatibility complex. A sex-specific polygenic DNA methylation score was generated to evaluate the pain status of each individual and confirmed in The Validation Cohort using pyrosequencing.

2021-11-10 | GSE162350 | GEO

A genome-wide cell-free DNA methylation analysis identifies an episignature associated with metastatic luminal B breast cancer.

Project description:Breast cancers of the luminal B subtype are frequent tumors with high proliferation and poor prognosis. Epigenetic alterations have been found in breast tumors and in biological fluids. We aimed to profile the cell-free DNA (cfDNA) methylome of metastatic luminal B breast cancer (LBBC) patients using an epigenomic approach to discover potential noninvasive biomarkers. Plasma cfDNA was analyzed using the Infinium MethylationEpic array (EPIC array) in a cohort of 14 women, including metastatic LBBC patients and healthy controls.

2022-11-16 | GSE214344 | GEO

Aspirin Suppresses Age-Related Methylation Drift in Healthy Colon by Targeting Epigenetic Regulators

Project description:DNA of 124 normal mucosa biopsies from cecum (proximal) and sigmoid (distal) colon obtained at baseline (t1) and after 10years (t2) from 31 screening females was subjected to measure DNA methylation profiles by Illumina Infinium EPIC Human Methylation BeadChip across approximately 850,000 CpGs.

2020-11-09 | GSE142257 | GEO

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