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Nc886, a noncoding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer

ABSTRACT: nc886 is a 101 nucleotides long non-coding RNA that is also known as a precursor microRNA or a vault RNA. nc886 has been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). In order to understand potential roles of nc886 in gastric cancer, we performed the knockdown of nc886 in nonmalignant HFE-145 cells and identified and analyzed genes whose expression is activated by nc886 knockdown in gastric cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51067 | GEO | 2015/09/30

SECONDARY ACCESSION(S): PRJNA220982

REPOSITORIES: GEO

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Epigenetic silencing of noncoding RNA nc886 provokes oncogenes during esophageal tumorigenesis

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