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DNA methylation profile in well-differentiated cancer uncoves another source of diagnostic and prognostic markers

ABSTRACT: By characterizing at the genome-wide level the DNA methylation patterns of the largest series of well-differentiated thyroid tumors described to date, we provide novel insights into the biology underlying on the one hand the histological heterogeneity, and on the other differential patient outcomes of this disease. We describe distinct subtype- and mutational-specific methylation profiles as well as novel markers associated with recurrence-free survival, which could provide an improved classification of patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51090 | GEO | 2014/07/31

SECONDARY ACCESSION(S): PRJNA221151

REPOSITORIES: GEO

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