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Genes regulated by TAZ in lung cancer cell lines

ABSTRACT: To investigate the roles of TAZ in lung cancer cell proliferation, we compared the expression profiles of A549 and H441 lung adenocarcinoma cell lines transfected with control siRNA and siTAZ.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51270 | GEO | 2014/06/25

SECONDARY ACCESSION(S): PRJNA222276

REPOSITORIES: GEO

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Genes regulated by TAZ in lung cancer cell lines

Project description:To investigate the roles of TAZ in lung cancer cell proliferation, we compared the expression profiles of A549 and H441 lung adenocarcinoma cell lines transfected with control siRNA and siTAZ. We collected RNA from A549 and H441 cell lines transfected with control siRNA and siTAZ.

2014-06-25 | E-GEOD-51270 | biostudies-arrayexpress

Genes regulated by TAZ in a lung fibroblast cell line

Project description:To investigate the roles of TAZ in lung fibroblasts, we compared the expression profiles of a lung fibroblast cell line, HFL-1, transfected with control siRNA and siTAZ.

2017-02-17 | GSE73555 | GEO

Genes regulated by TAZ or YAP in A549 cell

Project description:To investigate the roles of TAZ and YAP in lung cancer cell proliferation, we compared the expression profiles of A549transfected with control siRNA, siTAZ, and siYAP.

2020-02-29 | GSE111130 | GEO

Role of TAZ as mediator of Wnt signaling (MII)

Project description:To investigate the role of TAZ downstream of APC and beta-catenin in mammary epithelial cells cells, we compared the expression profiles of MCF10-T1k (MII) cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Keywords: expression profiling by array We collected RNA from MII cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Cells were left untreated in normal culturing conditions before harvesting. Samples were then processed for total RNA extraction and hybridization on Affymetrix microarrays. Four biological replicas (A, B, C, D) were used for each of the 5 conditions (1: siControl, control cells; 2: siAPC cells; 3: siAPC+siTAZ cells; 4: sibeta-catenin (sibcat) cells; 5: sibeta-catenin+siTAZ) for a total of 20 samples.

2012-12-21 | E-GEOD-39902 | biostudies-arrayexpress

Role of TAZ as mediator of Wnt signaling (MII)

2012-12-21 | GSE39902 | GEO

The lncRNA TAZ-AS202 promotes lung cancer progression through stabilization of the E2F1 transcription factor and activation of Ephrin signaling

Project description:Silencing of TAZ (WWTR1) and lncRNA TAZ-AS202 (WWTR1-AS1-202) by siRNA transfection on A549 cell line of lung cancer

2023-12-07 | E-MTAB-12507 | biostudies-arrayexpress

The effect of YAP/TAZ knockdown on the intestinal epithelium

Project description:The Hippo pathway plays a crucial in organ size control during development and tissue homeostasis in adult life. To examine a role for Hippo signaling in the intestinal epithelium, we analyzed gene expression patterns in the mouse intestinal epithelilum transfected with siRNAs or expression plasmids for shRNAs targeting the Hippo pathway effectors, YAP and TAZ. We performed two independent series of experiments (siGFP (n=3) vs siYAP/siTAZ (n=3), and shLacZ (n=1) vs shYAP/shTAZ (n=1)). Control siRNA (siGFP), YAP/TAZ siRNAs, or expression plasmids for control shRNA (shLacZ) or YAP/TAZ shRNAs were introduced into the mouse intestinal epithelium by the newly-developed in vivo transfection method. Four days after transfection, intestinal epithelial cells were isolated from the tissues and total RNA was extracted.

2014-07-18 | E-GEOD-45155 | biostudies-arrayexpress

Role of TAZ as mediator of Wnt signaling (SW480)

Project description:To investigate the role of TAZ downstream of the abberrant Wnt signaling in CRC cells, we compared the expression profiles of parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or reconstituted with wild type APC and transfected with siControl Keywords: expression profiling by array We collected RNA from parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or from SW480 cells reconstituted with wild type APC and transfected with siControl. Cells were left untreated in normal culturing conditions before harvesting. Samples were then processed for total RNA extraction and hybridization on Affymetrix microarrays. Four biological replicas (A, B, C, D) were used for each of the 4 conditions (1: siControl, control cells; 2: siTAZ cells; 3: sibeta-catenin (sibcat) cells; 4.APC reconstituted cells) for a total of 16 samples.

2012-12-21 | E-GEOD-39904 | biostudies-arrayexpress

Role of TAZ as mediator of Wnt signaling (SW480)

2012-12-21 | GSE39904 | GEO

YAP/TAZ-regulated gene expression in human airway epithelial cells

Project description:RNA sequencing was performed in samples isolated from primary normal airway epithelial cells, primary dysplastic airway epithelial cells (SPORE 43672) and immortalized cells (AALE), all of which were either transfected with control siRNA or with siRNA promoting the knockdown of the transcriptional regulators YAP (YAP1) and TAZ (WWTR1).

2021-06-08 | GSE133003 | GEO

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