Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE51296 | GEO | 2013/10/01

SECONDARY ACCESSION(S): PRJNA222319

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-10-01 | E-GEOD-51296 | biostudies-arrayexpress

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain.

Project description: Not available

| S-EPMC3763368 | biostudies-literature

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [DRG tissue]

Project description:Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I HDACIs were delivered intrathecally into rat spinal cord in models of traumatic nerve injury and antiretroviral drug-induced peripheral neuropathy (stavudine, d4T). Mechanical and thermal hypersensitivity was attenuated by 40% to 50% as a result of HDACI treatment, but only if started before any insult. The drugs globally increased histone acetylation in the spinal cord, but appeared to have no measurable effects in relevant dorsal root ganglia in this treatment paradigm, suggesting that any potential mechanism should be sought in the central nervous system. Microarray analysis of dorsal cord RNA revealed the signature of the specific compound used (MS-275) and suggested that its main effect was mediated through HDAC1. Taken together, these data support a role for histone acetylation in the emergence of neuropathic pain. n = 4, HDACi treated vs. vehicle treated. Injured ipsilateral DRG after L5 spinal nerve transection. Spinal cord tissue was run in a separate Affymetrix experiment.

2013-10-01 | E-GEOD-51295 | biostudies-arrayexpress

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [spinal cord tissue]

Project description:Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I HDACIs were delivered intrathecally into rat spinal cord in models of traumatic nerve injury and antiretroviral drug-induced peripheral neuropathy (stavudine, d4T). Mechanical and thermal hypersensitivity was attenuated by 40% to 50% as a result of HDACI treatment, but only if started before any insult. The drugs globally increased histone acetylation in the spinal cord, but appeared to have no measurable effects in relevant dorsal root ganglia in this treatment paradigm, suggesting that any potential mechanism should be sought in the central nervous system. Microarray analysis of dorsal cord RNA revealed the signature of the specific compound used (MS-275) and suggested that its main effect was mediated through HDAC1. Taken together, these data support a role for histone acetylation in the emergence of neuropathic pain. n = 4, HDACi treated vs. vehicle treated. Ipsilateral dorsal spinal cord tissue after L5 spinal nerve transection, DRG tissue was run in a separate Affymetrix experiment.

2013-10-01 | E-GEOD-51294 | biostudies-arrayexpress

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [DRG tissue]

2013-10-01 | GSE51295 | GEO

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [spinal cord tissue]

2013-10-01 | GSE51294 | GEO

Histone deacetylase inhibitors prevent persistent hypersensitivity in an orofacial neuropathic pain model.

Project description: Not available

| S-EPMC6124181 | biostudies-literature

Human iPSC-derived GABAergic Interneuron Transplants Attenuate Neuropathic Pain

Project description:Neuropathic pain causes severe suffering and most patients are resilient to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide relief from pain. However, the source of these precursor cells and their multipotent status make them unsuitable for therapeutic use. Here we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated hiPSC-derived GABAergic (iGABAergic) neurons provide significant, long-term and safe relief from neuropathic pain induced by peripheral nerve injury in mice. Furthermore, iGABAergic Neuron transplants survive long term in the injured spinal cord and show evidence of synaptic integration. Together, this provides the proof in principle for the first viable GABAergic transplants to treat human neuropathic pain patients.

2020-01-23 | GSE115565 | GEO

Distinct microglial transcriptional responses during opioid exposure or neuropathic pain

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-01-03 | GSE117321 | GEO

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Project description: Not available

| S-EPMC4138306 | biostudies-literature