Analyses of the chromatin and transcriptional basis for lateral inhibition in isolated intestinal epithelial cells.

ABSTRACT: We analyzed chromatin modifications, DNaseI-hypersensitive sites, and occupancy of a key secretory-lineage transcription factor, ATOH1. We found that lateral inhibition in the intestine occurs through ATOH1 exerting direct control within a broadly permissive chromatin state that is established in stem cells and is highly similar in specified progenitors of divergent potential.

ORGANISM(S): Mus musculus

PROVIDER: GSE51458 | GEO | 2014/01/06

SECONDARY ACCESSION(S): PRJNA223243

REPOSITORIES: GEO