Transcriptomics,Genomics

Dataset Information

59

Expression data of human aortic valve cusps


ABSTRACT: Calcific aortic valve disease is the most common form of valvular heart disease in the Western World. Milder degrees of aortic valve calcification is called aortic sclerosis and severe calcification with impaired leaflet motion is called aortic stenosis. We used microarrays to detail the global programme of gene expression underlying cdevelopment of calcified aortic valve disease in humans. Overall design: Human aortic valves from during different stages of develoment of calcified aortic valve disease (normal, sclerotic, calcified) was selected for RNA extraction and hybridization on Affymetrix microarrays. All the patients were male.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Jaana Rysa  

PROVIDER: GSE51472 | GEO | 2015-10-01

SECONDARY ACCESSION(S): PRJNA223273

REPOSITORIES: GEO

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Publications

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.

Ohukainen Pauli P   Syväranta Suvi S   Näpänkangas Juha J   Rajamäki Kristiina K   Taskinen Panu P   Peltonen Tuomas T   Helske-Suihko Satu S   Kovanen Petri T PT   Ruskoaho Heikki H   Rysä Jaana J  

Annals of medicine 20150730 5


Calcific aortic valve disease (CAVD) is a progressive pathological condition with no effective pharmacological therapy. To identify novel molecular pathways as potential targets for pharmacotherapy, we studied microRNA (miRNA) profiles of heavily stenotic aortic valves (AS). One of the most upregulated miRNAs in AS valves compared to control valves was miR-125b (1.4-fold; P < 0.05). To identify CAVD-related changes in gene expression, DNA microarray analysis was performed, including an intermedi  ...[more]

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