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Global gene expression profiling of guinea pig whole-lung and hindlimb muscles following long-term exposure to cigarette smoke and/or hypoxia

ABSTRACT: Despite intense efforts the molecular understanding of this clinically important extra pulmonary manifestation is still limited. Cigarette smoking is the main risk factor for developing COPD and therefore animal chronic smoking models have been proposed for mechanistic studies and biomarker discovery. The overarching aim of our study was to assess whether GP hindlimb muscles (both oxidative and glycolytic) show a transcriptional response to these exposures, and whether such gene signatures can be correlated to the expression of lung secreted proteins.

ORGANISM(S): Cavia porcellus

PROVIDER: GSE51601 | GEO | 2014/08/11

SECONDARY ACCESSION(S): PRJNA223671

REPOSITORIES: GEO

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Global gene expression profiling of guinea pig whole-lung and hindlimb muscles following long-term exposure to cigarette smoke and/or hypoxia

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