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Effects of acute Notch activation on the mammary epithelial compartment in vivo

ABSTRACT: Notch signaling is widely implicated in mouse mammary gland development and tumorigenesis. To investigate the effects of acute activation of Notch signaling in the mammary epithelial compartment, we generated bi-transgenic MMTV-rtTA; TetO-NICD1 (MTB/TICNX) mice that conditionally express a constitutively active NOTCH1 intracellular domain (NICD1) construct in the mammary epithelium upon doxycycline administration.

ORGANISM(S): Mus musculus

PROVIDER: GSE51628 | GEO | 2015/05/12

SECONDARY ACCESSION(S): PRJNA224113

REPOSITORIES: GEO

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