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Generation of functional cholangiocytes from human pluripotent stem cells and HepaRG cells

ABSTRACT: Gene expression profile analysis allowed to identify a panel of genes and pathways characteristic of hESC-and HepaRG-derived cholangiocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51791 | GEO | 2013/10/28

SECONDARY ACCESSION(S): PRJNA225031

REPOSITORIES: GEO

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Generation of functional cholangiocytes from human pluripotent stem cells and HepaRG cells

Project description:Gene expression profile analysis allowed to identify a panel of genes and pathways characteristic of hESC-and HepaRG-derived cholangiocytes. Microarrays were conducted at day 23 and day 10 of differentiation for hESC-Chol and HepaRG-Chol respectively and compared to hESC-HB and HepaRG-HB. Five, four or three independent experiments were performed depending the experimental sample

2013-10-28 | E-GEOD-51791 | biostudies-arrayexpress

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Acquisition of stem cell properties in tumor-derived hepatocyte-like cells leads to metabolic reprogramming and chemoresistance

Project description:Gene expression profile analysis allowed to identify a panel of genes and pathways characteristic of HepaRG Sphere-forming cells and HepaRG Side population

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Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells

Project description:The ever-increasing therapeutic and pharmaceutical demand for liver cells calls for systems that enable mass production of hepatic cells. Here we describe a large-scale suspension system that uses human endoderm stem cells (hEnSCs) as precursors to generate functional and transplantable hepatocytes (E-heps) or cholangiocytes (E-chos). hEnSC-derived hepatic populations are characterized by single-cell transcriptomic analyses and compared with hESC-derived counterparts, in-vitro-maintained or -expanded primary hepatocytes and adult cells, which reveals that hepatic differentiation of hEnSCs recapitulates in vivo development and that the heterogeneities of the resultant populations can be manipulated by regulating the EGF and MAPK signaling pathways. Functional assessments demonstrate that E-heps and E-chos possess properties comparable with adult counterparts and that, when transplanted intraperitoneally, encapsulated E-heps were able to rescue rats with acute liver failure. Our study lays the foundation for cell-based therapeutic agents and in vitro applications for liver diseases.

2021-04-20 | GSE128060 | GEO

Hepatocytes-HepaRG reprogramming.

Project description:To identify the molecular mechanisms and environmental inducers contributing to reprogramming of hepatocytes into progenitors in HCC context, we used the HepaRG cell line as model.

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Project description: Not available

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