Dataset #2 for genome-wide analysis of heritable dog osteosarcoma in 3 breeds

ABSTRACT: Osteosarcoma in dogs is a spontaneously occurring disease with a global tumor gene expression signature indistinguishable from human pediatric tumors and clinical progression is remarkably similar. Unlike human OS, canine OS is a highly heritable disease with some large and giant dog breeds at >10x increased risk. We did a genome wide association study of osteosarcoma using the Illumina CanineHD genotyping array in three breeds: greyhound (mortality from OS = 26%), rottweiler (17%) and Irish wolfhound (IWH, 21%) and identified 33 inherited risk loci explaining 55 to 85% of phenotype variance in each breed.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE51976 | GEO | 2013/11/12

SECONDARY ACCESSION(S): PRJNA227158

REPOSITORIES: GEO