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Role of CD26 on oncogenic gene expression

ABSTRACT: Purpose: Investigate a mechanism of CD26 to promote tumor progression in mesothelioma. Background: CD26 play a role on tumor progression and is expressed in many kinds of human malignancy, including mesothelioma, renal cell carcinoma, and T cell leukemia/lymphoma. In mesothelioma, expression of CD26 is observed in mesothelioma cells, but not in non-neoplastic mesothelioma cells, suggesting a role of CD26 on tumor progression (Clin Cancer Res 13:4191-4200, 2007). CD26 is known to activate T-cells through associating with adenosine deaminase, mannose 6-phosphatic/insulin-like growth factor II receptor, or with CD45RO (Immunol Res 161:55-70, 1998). However, mechanism of CD26 to promote tumor progression was not known.

ORGANISM(S): Homo sapiens

PROVIDER: GSE52216 | GEO | 2014/12/01

SECONDARY ACCESSION(S): PRJNA227409

REPOSITORIES: GEO

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