Single-cell measurements of osteolineage cells within the bone marrow cell niche

ABSTRACT: We report an approach biased only by the anatomic proximity of hematopoietic stem/progenitor cells (HSPC) to a putative niche cell as the criterion for molecular analysis. Comparative RNA-Seq profiling of single mesenchymal cells immediately proximal to transplanted HSPCs and those located further away revealed that HSPC-proximal cells have a distinct genome-wide transcriptional signature, highly enriched for genes previously implicated in HSPC niche function.

ORGANISM(S): Mus musculus

PROVIDER: GSE52359 | GEO | 2016/07/13

SECONDARY ACCESSION(S): PRJNA227569

REPOSITORIES: GEO