The nucleosomal barrier to promoter escape by RNA Polymerase II is overcome by the chromatin remodeler Chd1 [HiSeq]

ABSTRACT: We use a metabolic labeling strategy for directly measuring nucleosome turnover to determine the role of chromatin remodeler Chd1 on chromatin dynamics in mouse embryonic fibroblasts expressing with wildtype-Chd1 and dominant negative K510R-Chd1. We find that expression of K5 10R-Chd1 decreases nucleosome turnover at the promoter and increases turnover within the gene body.

ORGANISM(S): Mus musculus

PROVIDER: GSE52501 | GEO | 2014/04/15

SECONDARY ACCESSION(S): PRJNA229126

REPOSITORIES: GEO