Gene regulation in human epidermal keratinocytes by a Rho kinase inhibitor (Y-27632)

ABSTRACT: We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. Here, gene expression analysis of primary human epidermal keratinocytes cells grown in the presence of Y-27632 demonstrates that ROCK inhibition primarily inhibits keratinocyte differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE52515 | GEO | 2014/03/31

SECONDARY ACCESSION(S): PRJNA229149

REPOSITORIES: GEO