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C. tropicalis cells under in vitro biofilm-forming conditions

ABSTRACT: Transcriptional profiling of a-type wor1 deleted cells and mixed a-type and alpha-type opaque cells under in vitro biofilm-forming conditions. Specifically, they were grown for two days at room temperature in a 12-well poly-styrene plate containing 1 ml of Lee's + Glucose liquid media. Samples were hybridized against a universal mixed reference sample of a-type cells in white and opaque states grown in Spider liquid media.

ORGANISM(S): Candida tropicalis

PROVIDER: GSE52634 | GEO | 2013/11/22

SECONDARY ACCESSION(S): PRJNA229504

REPOSITORIES: GEO

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C. tropicalis cells under in vitro biofilm-forming conditions

Project description:Transcriptional profiling of a-type wor1 deleted cells and mixed a-type and alpha-type opaque cells under in vitro biofilm-forming conditions. Specifically, they were grown for two days at room temperature in a 12-well poly-styrene plate containing 1 ml of Lee's + Glucose liquid media. Samples were hybridized against a universal mixed reference sample of a-type cells in white and opaque states grown in Spider liquid media. 2 condition experiment: white wor1-deletion mutant a-type cells, opaque mixed a-type and alpha-type cells; two biological replicates each.

2013-11-22 | E-GEOD-52634 | biostudies-arrayexpress

C. tropicalis a biofilms of opaque and wor1 overexpressers

Project description:Transcriptional profiling of C. tropicalis a cells (CAY1503) in opaque state and overexpressing Wor1 in biofilms hybridized against a universal mixed reference sample of a cells in white and opaque states grown in Spider liquid.

2013-05-01 | GSE43267 | GEO

C. tropicalis a biofilms of opaque and wor1 overexpressers

2013-05-01 | E-GEOD-43267 | biostudies-arrayexpress

C. tropicalis a/alpha white, opaque, tdh3-wor, wor1 mutants

Project description:Transcriptional profiling of C. tropicalis a/alpha cells (CAY1511) in white state, opaque state, overexpressing Wor1, or wor1 mutants hybridized against a universal mixed reference sample from all 4 states.

2013-03-01 | GSE42517 | GEO

C. tropicalis a/alpha white, opaque, tdh3-wor, wor1 mutants

2013-03-01 | E-GEOD-42517 | biostudies-arrayexpress

Opaque filamentation in Low Phosphate (LP) and Sorbitol (SOR) compared to in SCD

2013-04-01 | GSE42963 | GEO

Opaque filamentation in Low Phosphate (LP) and Sorbitol (SOR) compared to in SCD

Project description:Act1-Wor1 strain (the opaque strain CAY2903 with constitute WOR1 expression), wildtype white (a/a RBY717); Opaque hyphal formation in liquid LP and SOR compared to SCD; white cells in the same conditions as control. 6 condition experiment: opaque and white cells in LP, SOR and SCD. Used the pool of all conditions as reference.

2013-04-01 | E-GEOD-42963 | biostudies-arrayexpress

Candida tropicalis

Project description:C. tropicalis a biofilms of opaque and wor1 overexpressers

| PRJNA185182 | ENA

Candida tropicalis

Project description:C. tropicalis a/alpha white, opaque, tdh3-wor, wor1 mutants

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The gray phenotype in the human fungal pathogen Candida tropicalis

Project description:Phenotypic plasticity, the ability to switch between different morphological types, plays critical roles in environmental adaptation, leading to infections, and allowing for sexual reproduction in pathogenic Candida species. Candida tropicalis, which is both an emerging human fungal pathogen and an environmental fungus, can switch between two heritable cell types termed white and opaque. In this study, we report the discovery of a novel phenotype in C. tropicalis, named the gray phenotype. Similar to Candida albicans and Candida dubliniensis, white, gray, and opaque cell types of C. tropicalis also form a tristable switching system, where gray cells are relatively small and elongated. In C. tropicalis, gray cells exhibit intermediate levels of mating competency and virulence in a mouse systemic infection model compared to the white and opaque cell types, express a set of cell type-enriched genes, and exhibit both common and species-specific biological features. The key regulators of white-opaque transitions, Wor1 and Efg1, are not required for the gray phenotype. A comparative study of the gray phenotypes in C. tropicalis, C. albicans, and C. dubliniensis provides clues to explain the species differences in terms of virulence, ecological niches, and prevalence among these three species.

2017-01-30 | GSE81514 | GEO

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