Ontology highlight
ABSTRACT:
INSTRUMENT(S): Nanostring Human miRNA Assay Kit (mirBase 17)
SUBMITTER: Oleg Butovsky
PROVIDER: GSE52670 | GEO | 2014-11-24
SECONDARY ACCESSION(S): PRJNA230490
REPOSITORIES: GEO
Butovsky Oleg O Jedrychowski Mark P MP Cialic Ron R Krasemann Susanne S Murugaiyan Gopal G Fanek Zain Z Greco David J DJ Wu Pauline M PM Doykan Camille E CE Kiner Olga O Lawson Robert J RJ Frosch Matthew P MP Pochet Nathalie N Fatimy Rachid El RE Krichevsky Anna M AM Gygi Steven P SP Lassmann Hans H Berry James J Cudkowicz Merit E ME Weiner Howard L HL
Annals of neurology 20141127 1
To investigate miR-155 in the SOD1 mouse model and human sporadic and familial amyotrophic lateral sclerosis (ALS).NanoString microRNA, microglia and immune gene profiles, protein mass spectrometry, and RNA-seq analyses were measured in spinal cord microglia, splenic monocytes, and spinal cord tissue from SOD1 mice and in spinal cord tissue of familial and sporadic ALS. miR-155 was targeted by genetic ablation or by peripheral or centrally administered anti-miR-155 inhibitor in SOD1 mice.In SOD1 ...[more]