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Time evolution study of sepsis in patients at D1, D7 and D28 post-inclusion

ABSTRACT: Microarray was performed on PBMC with an inflammatory dedicated slide of 340 genes, and target samples labelled with Cy3 for day 0 (reference) and with Cy5 for the other days. Changes in expression levels were evaluated by the ratio Dx/D0. According to time evolution, a two-dimensional clustering was performed. Keywords: time evolution of sepsis in patients at D1, D7 and D28 post-inclusion

ORGANISM(S): Homo sapiens

PROVIDER: GSE5271 | GEO | 2006/08/01

SECONDARY ACCESSION(S): PRJNA96377

REPOSITORIES: GEO

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Time evolution study of sepsis in patients at D1, D7 and D28 post-inclusion

Project description:Microarray was performed on PBMC with an inflammatory dedicated slide of 340 genes, and target samples labelled with Cy3 for day 0 (reference) and with Cy5 for the other days. Changes in expression levels were evaluated by the ratio Dx/D0. According to time evolution, a two-dimensional clustering was performed. The day of inclusion corresponded to the first blood sampling (15 ml) quoted day 0. The following blood samples were performed at days 1, 7, and 28. Since the pre-sepsis expression of the genes as a control cannot be obtained, the day 0 sample was used patient per patient as a reference value for the next days samples for micro-array study. Patients evolution was considered.

2010-07-01 | E-GEOD-5271 | biostudies-arrayexpress

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Project description:Among the childhood diseases, B-cell acute lymphocytic leukemia (B-ALL) is the most frequent type of cancer. In spite of recent advances concerning disease treatment, cytotoxic chemotherapy remains as the first line of treatment in several countries, and the modifications induced by such drugs in the organism remains poorly understood. In this context, the present study provided a comparative high-throughput proteomic analysis of the cumulative changes induced by chemotherapeutic drugs used in the induction phase of B-LLA treatment in both peripheral blood (PB) and bone marrow compartment (BM) samples. To reach this goal, PB and BM plasma samples were comparatively analyzed by using label-free proteomics at two endpoints: at diagnosis (D0) and the end of the cumulative induction phase treatment (D28). The resulting differentially expressed proteins were explored by bioinformatics approaches aiming to identify the main gene ontology processes, pathways and transcription factors altered by chemotherapy, as well to understand B-LLA biology in each compartment at D0. At D0, PB was characterized as a pro-inflammatory environment, with the involvement of several downregulated coagulation proteins as KNG, plasmin and plasminogen. D28 was characterized predominantly by immune response-related processes, and the super expression of the transcription factor IRF3 and transthyretin. RUNX1 was pointed out as a common transcription factor found in both D0 and D28. Considering that most of these proteins were not described in B-ALL literature, these findings added to understanding disease biology at diagnosis, and highlighted some important proteins and processes that may contribute to our understanding about the mechanisms concerning the impact of chemotherapy in disease resolution.

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