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Analysis of global gene expression profiles of A549 cells treated with SETX siRNA under basal conditions

ABSTRACT: Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were analyzed for gene expression differences under basal conditions

ORGANISM(S): Homo sapiens

PROVIDER: GSE52933 | GEO | 2015/03/30

SECONDARY ACCESSION(S): PRJNA230481

REPOSITORIES: GEO

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Analysis of global gene expression profiles of A549 cells treated with SETX siRNA under basal conditions

Project description:Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were analyzed for gene expression differences under basal conditions 3 Biological Replicates per condition

2015-03-30 | E-GEOD-52933 | biostudies-arrayexpress

Analysis of global gene expression profiles of A549 cells treated with SETX siRNA upon Influenza A/PR/8/34(ΔNS1) Infection

Project description:Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours

2015-03-30 | GSE52932 | GEO

Analysis of global gene expression profiles of A549 cells treated with SETX siRNA upon Influenza A/PR/8/34(ΔNS1) Infection

Project description:Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours 3 Biological Replicates per condition

2015-03-30 | E-GEOD-52932 | biostudies-arrayexpress

Analysis of global gene expression profiles of A549 cells treated with XRN2 siRNA under basal conditions

Project description:Untransfected (no siRNA), control siRNA or XRN2 siRNA treated A549 cells were analyzed for gene expression differences under basal conditions

2015-03-30 | GSE66662 | GEO

Analysis of global gene expression profiles of A549 cells treated with TOP1 siRNA under basal conditions

Project description:Untransfected (no siRNA), control siRNA or TOP1 siRNA treated A549 cells were analyzed for gene expression differences under basal conditions

2016-07-11 | GSE52931 | GEO

Analysis of global gene expression profiles of A549 cells treated with XRN2 siRNA under basal conditions

Project description:Untransfected (no siRNA), control siRNA or XRN2 siRNA treated A549 cells were analyzed for gene expression differences under basal conditions 3 Biological Replicates per condition

2015-03-30 | E-GEOD-66662 | biostudies-arrayexpress

Analysis of global gene expression profiles of A549 cells treated with Xrn2 siRNA upon Influenza A/PR/8/34(ΔNS1) Infection

Project description:Untransfected (no siRNA), control siRNA or Xrn2 siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours

2015-03-30 | GSE66661 | GEO

Analysis of global gene expression profiles of A549 cells treated with TOP1 siRNA upon Influenza A/PR/8/34(ΔNS1) Infection

Project description:Untransfected (no siRNA), control siRNA or TOP1 siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 12 hours

2016-07-11 | GSE52930 | GEO

Analysis of global gene expression profiles of A549 cells treated with Xrn2 siRNA upon Influenza A/PR/8/34(ΔNS1) Infection

Project description:Untransfected (no siRNA), control siRNA or Xrn2 siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours 3 Biological Replicates per condition

2015-03-30 | E-GEOD-66661 | biostudies-arrayexpress

SETX attenuates the antiviral innate immune response and controls viral biogenesis (GRO-Seq)

Project description:The innate immune response is the first line of defense against pathogens, and factors that control this cellular response represent targets for treating both infectious and inflammatory diseases. Here, we reveal a novel role for the human helicase SETX, also previously implicated in amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2), in controlling the magnitude of the antiviral response. Cells depleted for SETX and AOA2 patient-derived SETX-null cells show increased expression of antiviral mediators in response to infection. Mechanistically, this effect is achieved through SETX-mediated inhibition of RNAPII transcription of antiviral genes, and depends on SETX helicase activity. Our results suggest that SETX helps maintain the delicate balance between controlling viral infection and avoiding the potentially detrimental effects of an excessive antiviral response. More broadly, the observation that SETX can regulate the transcriptional activity of specific genes may have important implications for disorders where SETX function is compromised. A549 cells that were transfected with either control non-targeting or SETX-specific siRNAs were infected with the Influenza A virus (A/PR/8/34(ΔNS1) strain) at a multiplicity of infection (MOI) of 3 for 4 hours. Nuclei were then extracted and used to prepare Global Run-On Sequencing (GRO-seq) libraries.

2015-03-30 | E-GEOD-52935 | biostudies-arrayexpress

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