Characterization of Gene Expression in ASS1-Deficient Breast Cancer Cells

ABSTRACT: Analysis of mechanism underlying the metabolic effects of ADI-PEG20 at gene expression level. The hypothesis tested in the present study was that ASS1-deficient breast cancer cells would be arginine-auxotrophs and would therefore be sensitive to arginine starvation. Results provide important information of the response of ASS1-deficient breast cancer cells to ADI-PEG20-treatment, such as the suppression of mRNAs encoding mitochondrial respiratory chain proteins.

ORGANISM(S): Homo sapiens

PROVIDER: GSE53838 | GEO | 2014/05/20

SECONDARY ACCESSION(S): PRJNA233499

REPOSITORIES: GEO