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Adult postmortem brain tissue (dorsolateral prefrontal cortex) from subjects with bipolar disorder and healthy controls

ABSTRACT: Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing. Keywords: disease state analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE5388 | GEO | 2006/07/27

SECONDARY ACCESSION(S): PRJNA104325

REPOSITORIES: GEO

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Transcription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

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