Identification of beta-catenin binding regions in SW480 cells

ABSTRACT: Deregulation of canonical Wnt/beta-catenin pathway is one of the earliest events in the pathogenesis of colon cancer. Mutations in APC or CTNNB1 (beta-catenin gene) are highly frequent in colon cancer and cause aberrant stabilization of b-catenin, which activates the transcription of Wnt target genes by binding to chromatin via the TCF/LEF transcription factors. Here we report an integrative analysis of genome-wide chromatin occupancy of b-catenin by chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) and gene expression profiling by microarray analysis upon RNAi-mediated knockdown of beta-catenin in colon cancer cells (GSE53656).

ORGANISM(S): Homo sapiens

PROVIDER: GSE53927 | GEO | 2014/03/12

SECONDARY ACCESSION(S): PRJNA233973

REPOSITORIES: GEO