Genomics

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Gene expression profiles of LN3 T-ALL cells, and tumor-associated and WT thymic dendritic cell subsets


ABSTRACT: Thymic lymphomas develop spontaneously in LN3 mice. As for T-ALL in general, ex vivo LN3 lymphoma cells require stromal support to remain viable in culture. We found that primary stromal cells from thymic lymphomas, but not from wild-type thymi, support ex vivo lymphoma survival. By FACS sorting stromal populations, we identified dendritic cells in the tumor microenvironment as the cells capable of supporting lymphoma survival. We used microarrays to analyze the gene expression profiles of T-ALL cells and tumor-associated versus wild-type thymic dendritic cell subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE54609 | GEO | 2016/01/29

SECONDARY ACCESSION(S): PRJNA237158

REPOSITORIES: GEO

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