Inhibition of Hedgehog Signaling Pathway Impairs Cancer Cell Growth via Promotion of Autophagy

ABSTRACT: Analysis of gene expression levels in response to inhibition of Hh signaling in ovarian and glioma cancer cells using a cDNA microarray technique. Microarray analyses revealed that differentially expressed genes (DEGs) in human cancer cells are enriched in the senescence and autophagy pathways in response to the inhibition of Hh signaling. Further investigations showed that inhibition of Hh signaling induced autophagy..

ORGANISM(S): Homo sapiens

PROVIDER: GSE54936 | GEO | 2014/06/15

SECONDARY ACCESSION(S): PRJNA238057

REPOSITORIES: GEO