Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Charting Brachyury-mediated Developmental Pathways During Early Mouse Embryogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE54985 | GEO | 2014/03/10

SECONDARY ACCESSION(S): PRJNA238201

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Charting Brachyury-mediated developmental pathways during early mouse embryogenesis.

Project description: Not available

| S-EPMC3970479 | biostudies-literature

Charting Brachyury-mediated Developmental Pathways During Early Mouse Embryogenesis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-10 | E-GEOD-54985 | biostudies-arrayexpress

MCRS1 is essential for epiblast development during early mouse embryogenesis.

Project description: Not available

| S-EPMC7431978 | biostudies-literature

Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis.

Project description: Not available

| S-EPMC8526749 | biostudies-literature

Uhrf1 loss alters Ctcf-mediated topological organization during early mouse embryogenesis

Project description:UHRF1 is a chromatin-binding protein essential for maintaining DNA methylation and histone modification states, yet its integrated role in vivo remains incompletely understood. To define its function, we generated conditional Uhrf1 knockout embryonic stem cells (ESCs) and embryos. Uhrf1⁻/⁻ ESCs exhibited near-complete loss of 5mC and 5hmC but maintained pluripotency, whereas Uhrf1-null embryos developed normally until E8.5 and then failed to further develop by E9.5, phenocopying Dnmt1 loss. Single-cell multi-omic (ME-seq) profiling of E8.5 embryos revealed impaired lineage stabilization, widespread hypomethylation, and disrupted chromatin architecture. Uhrf1 loss predicted altered CTCF occupancy, accompanied with disorganized enhancer-promoter interactions, and defective Bmp signaling, particularly within neural crest populations. These findings identify Uhrf1 as a central regulator tightly coupling DNA methylation maintenance to 3D genome organization during gastrulation to direct early lineage specification, positioning Uhrf1 as a pivotal mediator of epigenetic information transfer during early embryogenesis.

2026-03-15 | GSE308175 | GEO

Mouse emi1 has an essential function in mitotic progression during early embryogenesis.

Project description: Not available

| S-EPMC1592703 | biostudies-literature

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

Project description: Not available

| S-EPMC3132516 | biostudies-other

Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure.

Project description: Not available

| S-EPMC3556627 | biostudies-literature

Developmental regulation of mRNA species for types II, IX and XI collagens during mouse embryogenesis.

Project description: Not available