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Gene expression differences underlying genotype-by-genotype specificity in a host-parasite system

ABSTRACT: Expression of bumblebees (Bombus terrestris) from four colonies exposed to 3 different genotypes of the trypanosome parasite Crithidia bombi

ORGANISM(S): Bombus terrestris

PROVIDER: GSE55035 | GEO | 2014/04/28

SECONDARY ACCESSION(S): PRJNA238307

REPOSITORIES: GEO

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Gene expression differences underlying genotype-by-genotype specificity in a host-parasite system

Project description:Expression of bumblebees (Bombus terrestris) from four colonies exposed to 3 different genotypes of the trypanosome parasite Crithidia bombi RNA from guts of exposed individuals. Sacrificed 18hr after exposure.

2014-04-28 | E-GEOD-55035 | biostudies-arrayexpress

MiRNAs in the genomes of Bombus terrestris and Bombus impatiens

Project description:Our aims in this study were: 1) to identify the miRNAs of the bumble bees Bombus terrestris and B. impatiens; 2) to compare the total numbers of miRNAs between both bumble bee species and between them and the honey bee, Apis mellifera; and 3) to test whether the sequences and expression patterns of miRNAs were conserved between species. To investigate each of these aims we used miRNA-seq (deep sequencing of miRNA-enriched libraries) in B. terrestris, and bioinformatics prediction programs to identify miRNAs in both Bombus species. We identified 131 miRNAs in B. terrestris, and 114 in B. impatiens; of these, 17 were new miRNAs that had not previously been sequenced in any species. We found a striking level of difference in the miRNAs present between Bombus and A. mellifera, with 103 miRNAs in A. mellifera not being present in the genomes of the two bumble bees. miRNA profiles of Bombus terrestris at two developmental stages in larvae. This submission represents 'Bombus terrestris' component of study.

2015-03-06 | E-GEOD-64512 | biostudies-arrayexpress

Gene expression differences underlying genotype-by-genotype specificity in a host-parasite system.

Project description: Not available

| S-EPMC3948297 | biostudies-literature

MiRNAs in the genomes of Bombus terrestris and Bombus impatiens

2015-03-06 | GSE64512 | GEO

A domino effect in drug action: From metabolic assault towards parasite differentiation

Project description:Glycolysis is the sole free-energy source for the deadly parasite Trypanosoma brucei and is therefore a possible target pathway for anti-trypanosomal drugs. Plasma-membrane glucose transport exerts high control over trypanosome glycolysis and hence the transporter is a promising drug target. Here we show that at high inhibitor concentrations, inhibition of trypanosome glucose transport causes cell death. Most interestingly, sublethal concentrations initiate a domino effect in which network adaptations enhance inhibition.

2010-10-18 | GSE24275 | GEO

A domino effect in drug action: From metabolic assault towards parasite differentiation

2010-10-18 | E-GEOD-24275 | biostudies-arrayexpress

Bombus Terrestris

Project description:Bombus Terrestris Other

| PRJNA438866 | ENA

Bombus terrestris

Project description:Bombus terrestris overview

| PRJNA839077 | ENA

Bombus terrestris

Project description:Bombus terrestris overview

| PRJNA45887 | ENA

Genome-wide identification of accessible chromatin regions in bumblebee by ATAC-seq

Project description:Bumblebees (Hymenoptera: Apidae) are important pollinating insects that play pivotal roles in crop production and natural ecosystem services. To achieve a comprehensive profile of accessible chromatin regions and provide clues for all possible regulatory elements in the bumblebee genome, we did ATAC-seq for Bombus terrestris samples derived from its four developmental stages: egg, larva, pupa, and adult, respectively. The sequencing reads of ATAC-seq were mapped to B. terrestris reference genome, and its accessible chromatin regions were identified and characterized using bioinformatic methods. Our study will provide important resources not only for uncovering regulatory elements in the bumblebee genome, but also for expanding our understanding of bumblebee biology.

2020-10-02 | GSE151858 | GEO

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