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Dendritic Cell Fate is Determined by BCL11A

ABSTRACT: Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of E2-2 and other pDC differentiation modulators including ID2 and MTG16. Our results identify BCL11A as an essential, lineage-specific factor that regulates pDC development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55043 | GEO | 2014/02/15

SECONDARY ACCESSION(S): PRJNA238319

REPOSITORIES: GEO

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Dendritic Cell Fate is Determined by BCL11A

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