Reduced Expression of the Proto-oncogene Myc Increases Mouse Longevity and Enhances Healthspan

ABSTRACT: MYC is a pleiotropic transcription factor that regulates numerous pathways and whose deregulation promotes cancer. Myc+/- mice have extended lifespan relative to their wild type littermates. To better understand the effects of the Myc+/- genotype on cellular processes, microarrays were performed on young (5 month) and old (24 month) Myc+/- and WT males in liver, skeletal muscle, and adipose tissues. Microarray data were used to compare the effects of aging with the effects of the Myc+/- genotype at each age, to identify pathways enriched for differentially expressed genes, and to compare the Myc+/- gene expression signature with that from other long-lived mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE55272 | GEO | 2014/02/22

SECONDARY ACCESSION(S): PRJNA239025

REPOSITORIES: GEO