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Transcriptome analysis of Corynebacterium glutamicum in response to furfural presence

ABSTRACT: To understrand the altered global gene expression levels in C. glutamicum wild type in presence of furfural, transcriptome profiling was performed.

ORGANISM(S): Corynebacterium glutamicum Corynebacterium glutamicum ATCC 13032

PROVIDER: GSE55516 | GEO | 2015/01/01

SECONDARY ACCESSION(S): PRJNA239820

REPOSITORIES: GEO

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Transcriptome analysis of Corynebacterium glutamicum in response to furfural presence

Project description:To understrand the altered global gene expression levels in C. glutamicum wild type in presence of furfural, transcriptome profiling was performed. Transcriptome profiles of the wild type grown in CgXII medium without furfural and with furfural stresses (each 6.5 mM, 13 mM, and 20 mM) were compared by using the samples taken at the OD600 of 6 (for the control and experiments). Each experiment was performed with a duplicate.

2015-01-01 | E-GEOD-55516 | biostudies-arrayexpress

Corynebacterium glutamicum ATCC 13032

Project description:Transcriptome analysis of Corynebacterium glutamicum in response to furfural presence

| PRJNA239820 | ENA

Transcriptional response of Corynebacterium glutamicum ATCC 13032 to 2.5 mM indole

Project description:Differential gene expression analysis of C. glutamicum ATCC 13032 in presence of 2.5 mM indole compared to control conditions without indole. C. glutamicum ATCC 13032 cells were cultivated in CGXII minimal medium with 40 g per litre glucose in presence of 2.5 mM indole and harvested during exponential phase (o.d.600 4).

2020-12-31 | GSE159887 | GEO

Transcriptional response of Corynebacterium glutamicum C1 to 3 mM indole-alanine dipeptide

Project description:Differential gene expression analysis of C. glutamicum C1 in presence of 3 mM indole-alanine dipeptide compared to control conditions without indole-alanine dipeptide. C. glutamicum C1 cells were cultivated in CGXII minimal medium with 40 g per litre glucose in presence or absence of 3 mM indole-alanine dipeptide and harvested during exponential phase (o.d.600 6).

2020-12-31 | GSE159888 | GEO

Iron deficiency response of Corynebacterium glutamicum

Project description:The response to iron limitation of the Gram-positive soil bacterium Corynebacterium glutamicum was analyzed with respect to proteome during growth in glucose minimal medium. C. glutamicum cells were grown at regular (36 µM) and low (1 µM) iron concentrations and harvested in the late exponential growth phase. Between 1056 and 1357 proteins were detected (1% false discovery rate, FDR) in the measurements of three biological replicates including technical replicates each for low and high iron conditions with a proteomic shotgun analysis using nanoLC-MS/MS, covering in total 1555 proteins. By SWATH-MS measurements, relative levels of 1123 proteins could be quantified. Thereof, 66 proteins exhibited at least two-fold altered ratios with a p-value ≤0.05 in iron-deprived cells compared to the cells cultivated with 36 μM iron. 38 proteins showed a ≥2-fold higher level under iron limitation, 16 of which were members of the DtxR regulon. The levels of 28 proteins were at least 2-fold lower under iron limitation, 10 of which were members of the RipA regulon.

2020-04-15 | PXD017349 | Pride

To study gene expression by xylose fermenting strains in the presence and absence of furfural

Project description:The main objective is to develop a strain tolerant to furfural for ethanol production from lignocellulosic hydrolysates. We compare gene expressions among three genetically modified S. cerevisiae (control, TAL-expressing and TAL-ADH expressing strain) under the presence and absence of furfural.

2013-06-01 | GSE45273 | GEO

Comparison of Corynebacterium glutamicum Δsurf1 and wt

Project description:To identify genes which are differentially expressed in Corynebacterium glutamicum in the cg2460 deletion strain, we performed DNA microarray analyses of C. glutamicum Δcg2460 compared to the WT.

2019-07-11 | GSE123974 | GEO

Comparison of Corynebacterium glutamicum Δcg2699 with WT

Project description:To identify genes which are differentially expressed in Corynebacterium glutamicum in the cg2699 deletion strain, we performed DNA microarray analyses of C. glutamicum Δcg2699 compared to the WT.

2018-08-28 | GSE117566 | GEO

Determination of transcriptional start sites in the presence of GABA for Corynebacterium glutamicum

Project description:In this study, we analyzed the regulation of ƴ-aminobutyrate (GABA) utilization in Corynebacterium glutamicum by the PucR-type transcriptional regulator GabR and by alternative nitrogen and carbon sources.

2020-09-29 | GSE156688 | GEO

Revealing Corynebacterium glutamicum proteoforms through top-down proteomics

Project description:Corynebacterium glutamicum is a bacterium widely employed in the industrial production of amino acids as well as a broad range of other biotechnological products. The present study describes the characterization of C. glutamicum proteoforms, and their post-translational modifications (PTMs) employing top-down proteomics. Despite previous evidence of PTMs having roles in the regulation of C. glutamicum metabolism, this is the first top-down proteome analysis of this organism. We identified 1125 proteoforms from 273 proteins, with 60 % of proteins presenting at least one mass shift, suggesting the presence of PTMs, including several acetylated, oxidized and formylated proteoforms. Furthermore, proteins relevant to amino acid production, protein secretion, and oxidative stress were identified with mass shifts suggesting the presence of uncharacterized PTMs and proteoforms that may affect biotechnologically relevant processes in this industrial workhorse. For instance, the membrane proteins mepB and SecG were identified as a cleaved and a formylated proteoform, respectively. While in the central metabolism, OdhI was identified as two proteoforms with potential biological relevance: a cleaved proteoform and a proteoform with PTMs corresponding to a 70 Da mass shift.

2022-12-10 | PXD038038 | Pride

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