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Genome Wide Expression of Mammary Epithelial Populations in Slug (SNAI2) WT vs Slug Null Mice

ABSTRACT: This experiment shows differential expression of genes in the luminal, basal and stromal subpopulations from SNAI2+/+ and SNAI2 LacZ/LacZ mammary epithelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE55620 | GEO | 2014/03/08

SECONDARY ACCESSION(S): PRJNA240226

REPOSITORIES: GEO

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Genome Wide Expression of Mammary Epithelial Populations in Slug (SNAI2) WT vs Slug Null Mice

Project description:This experiment shows differential expression of genes in the luminal, basal and stromal subpopulations from SNAI2+/+ and SNAI2 LacZ/LacZ mammary epithelial cells. Luminal, basal and stromal populations were sorted from SNAI2+/+ and SNAI2 LacZ/LacZ mammary epithelial cells based on expression of CD49f and Epcam.

2014-03-08 | E-GEOD-55620 | biostudies-arrayexpress

Gene expression profiles of young and aged mammary epithelial and stromal cell populations from Wild Type and Slug/Snai2-null mice

Project description:This experiment shows RNA-Seq gene expression profiles of Wild Type and Slug/Snai2-null luminal, basal, and stromal mammary cell populations from young (3 mo) and aged (12 mo) mice.

2019-07-09 | GSE132127 | GEO

Genome-wide maps of SNAI2 binding in undifferentiated and differentiated keratinocytes

Project description:We report the ChIP-Seq results of SNAI2 in several different conditions which include: SNAI2 binding in both control and SNAI2 knockdown cells to demonstrate specificity of the binding. SNAI2 ChIP-Seq was also performed in SNAI2 or control LACZ overexpressing cells cultured in growth medium as well as LACZ or SNAI2 overexpressing cells in differentiation medium.

2014-10-15 | GSE55421 | GEO

Genome-wide maps of SNAI2 binding in undifferentiated and differentiated keratinocytes

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Transcript Analysis of Human Mammary Cell Subsets using SAGE

Project description:Highly purified subpopulations of primitive bipotent and committed luminal progenitor cells as well as mature luminal and myoepithelial cells from normal human mammary tissue were isolated and compared their transcriptomes which were obtained using PCR-Long-SAGE technology. Keywords: mammary progenitors, stem cells, Notch signaling, gene expression Four SAGE libraries were constructed on RNA samples extracted from highly purified subpopulations of primitive bipotent and committed luminal progenitor cells as well as mature luminal and myoepithelial cells isolate from a normal human mammary tissue.

2008-05-09 | E-GEOD-11387 | biostudies-arrayexpress

Gene expression profiles of normal mouse mammary cell subpopulations FACS sorted based on expression of biomarkers

Project description:To delineate epithelial subpopulations in mouse mammary tissue, hematopoietic and endothelial cells were depleted from freshly isolated cell suspensions derived from mammary glands using fluorescence-activated cell sorting. The resultant Lin- population was fractionated into four distinct subpopulations using antibodies against CD29, CD24 and CD61. Based on the immunohistochemical phenotype, and in vivo and in vitro functional assays, these subpopulations were identified as fibroblast-containing stromal (CD29loCD24-), mammary stem cell (MaSC)-enriched (CD29hiCD24+CD61+), luminal progenitor (CD29loCD24+CD61+), and mature luminal (CD29loCD24+CD61-) cell subpopulations. Microarray profiling was used to derive gene expression signatures of these 4 subpopulations. The four mammary cell subpopulations were found to have distinct gene expression profiles. Four mammary cell subpopulations from 3-5 pooled mouse tissues were analysed. MS is for the MaSC-enriched cell subpopulation. LP is for the Luminal Progenitor subpopulation. ML is for the Mature Luminal subpopulation.

2010-03-20 | E-GEOD-19446 | biostudies-arrayexpress

Snai2 influences breast cancer evolution in a non-cell autonomous manner

Project description:SNAI2 is a transcription factor involved in multiple processes in both physiology and pathology, including apoptosis, epithelial-mesenchymal transition and tumorigenesis. The effects of SNAI2 on the epithelial compartment have been interpreted as an effect of its expression and action in that compartment. In this work, we demonstrated that the absence of Snai2 in other compartments has repercussions in different aspects of the behavior of the epithelial cells of luminal breast tumors, developed by MMTV-ErbB2/Neu transgenic mice that do not express SNAI2 in the epithelial component. The absent of SNAI2 in the stroma of these tumors is accompanied by different characteristics at histopathological and molecular levels than those having functional SNAI2. These results indicate that the expression of SNAI2 in the tumor niche contributes to the luminal tumor development and behavior.

2018-03-20 | GSE112052 | GEO

Gene expression data on human keratinocytes with knockdown or overexpression of SNAI2

Project description:1. Keratinocytes infected with retroviruses expressing control or SNAI2 shRNAs were cultured in growth medium and Affymetrix HG-U133 plus 2.0 arrays were used to determine global gene expression profiles. 2. Keratinocytes infected with retroviruses overexpressing LACZ or SNAI2 were cultured in growth medium and Affymetrix HG-U133 plus 2.0 arrays were used to determine global gene expression profiles. Keratinocytes with knockdown or overexpression of SNAI2 were used to determine gene expression profiles

2014-10-15 | E-GEOD-55269 | biostudies-arrayexpress

Gene expression data on human keratinocytes with knockdown or overexpression of SNAI2

2014-10-15 | GSE55269 | GEO

Gene expression profiles of young and aged mammary epithelial and stromal cell populations from Wild Type and Slug/Snai2-null mice

Project description:Gene expression profiles of young and aged mammary epithelial and stromal cell populations from Wild Type and Slug/Snai2-null mice

| PRJNA545994 | ENA

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