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Loss and dysfunction of Vdelta2+ gammadelta-low T cells is associated with clinical tolerance to malaria

ABSTRACT: Gammadelta T cells from Ugandan children were tested for their responsiveness to stimulation with malaria parasites.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55843 | GEO | 2014/08/26

SECONDARY ACCESSION(S): PRJNA241119

REPOSITORIES: GEO

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Loss and dysfunction of Vdelta2+ gammadelta-low T cells is associated with clinical tolerance to malaria

Project description:Gammadelta T cells from Ugandan children were tested for their responsiveness to stimulation with malaria parasites. Independent PBMC samples from children were incubated with Plasmodium falciparum-infected red blood cells for 6 h post-treatment, and Vdelta2+ gammadelta T cells were double sorted by FACS directly into an RNA lysis buffer. RNA was isolated, amplified using 2 rounds of linear amplification, and hybridized to Agilent Human 8x60k microarrays as a single color experiment.

2014-08-26 | E-GEOD-55843 | biostudies-arrayexpress

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