Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Severe Hypoxia Exerts Parallel and Cell-specific Regulation of Gene Expression and Alternative Splicing in Human Mesenchymal Stem CellsMesenchymal Stem Cells

ABSTRACT: To identify the effects of hypoxia on stem cell populations, we subjected human mesenchymal stem cells to a pO2 of 4 mmHg and analyzed global gene expression and alternative splicing (AS) by genome-exon microarray.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55875 | GEO | 2014/03/14

SECONDARY ACCESSION(S): PRJNA241189

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Severe Hypoxia Exerts Parallel and Cell-specific Regulation of Gene Expression and Alternative Splicing in Human Mesenchymal Stem CellsMesenchymal Stem Cells

Project description:To identify the effects of hypoxia on stem cell populations, we subjected human mesenchymal stem cells to a pO2 of 4 mmHg and analyzed global gene expression and alternative splicing (AS) by genome-exon microarray. Hypoxia induced gene expression in human mesenchymal stem cells was measured at 24 hours after exposure to 0.5% oxygen or normal 21% oxygen. Three independent experiments were performed per condition (Hypoxia or Normoxia).

2014-03-14 | E-GEOD-55875 | biostudies-arrayexpress

Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells.

Project description: Not available

| S-EPMC4234502 | biostudies-literature

Gene expression in human umbilical cord vein and artery endothelial cells under physiological chronic normoxia (3% O2, PCN) and standard culture normoxia (21% O2, SCN)

Project description:Endothelial cells, and many other types of cells too, physiologically reside in low O2 environments (~ 2-13% O2 or 15-60 mmHg pO2; [PCN]) relevantly to atmospheric O2 (~ 21% or 160 mmHg pO2 at sea level) in vivo. Such PCN is critical for endothelial functions. The majority of our current knowledge regarding the cellular and signaling mechanisms governing endothelial functions, however, is built on endothelial models established under atmospheric O2 (~21% O2). Herein, we comapred the transcriptional profiles between HUVE and HUAE cells cultured and expanded under PCN (3% oxygen) and standard culture normoxia (21% O2).

2013-08-30 | GSE49958 | GEO

Gene expression in human umbilical cord vein and artery endothelial cells under physiological chronic normoxia (3% O2, PCN) and standard culture normoxia (21% O2, SCN)

2013-08-30 | E-GEOD-49958 | biostudies-arrayexpress

Hypoxia-induced alternative splicing in endothelial cells.

Project description: Not available

| S-EPMC3411717 | biostudies-literature

Expression and alternative splicing data of cartilage endplate-derived stem cells (CESCs) under hypoxia or normoxia

Project description:Cartilage endplate-derived stem cells (CESCs) with chondro-osteogenic differentiation capacity may be responsible for the balance of chondrification and ossification in cartilage endplate (CEP). CEP is an avascular and hypoxic tissue, and hypoxia could influence the fate of CESCs. We used high-throughput scanning to identify differentially expressed genes (DEGs) and alternatively spliced genes (ASGs) of CESCs under hypoxia compared to those under normoxia. Human cartilage endplate-derived stem cells (CESCs) were cultured under normoxia and hypoxia for 21 days respectively.

2016-07-18 | E-GEOD-84484 | biostudies-arrayexpress

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer.

Project description: Not available

| S-EPMC7294618 | biostudies-literature

Expression and alternative splicing data of cartilage endplate-derived stem cells (CESCs) under hypoxia or normoxia

2016-07-18 | GSE84484 | GEO

Hypoxia regulates alternative splicing of HIF and non-HIF target genes.

Project description: Not available

| S-EPMC4163527 | biostudies-literature

Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.

Project description: Not available

| S-EPMC7108908 | biostudies-literature