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Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [miRNA]

ABSTRACT: The microRNA changes induced in Primary Mouse Hepatocytes of C57Bl6-mice by Cyclosporin A after treatment for 24h and 48h

ORGANISM(S): Mus musculus

PROVIDER: GSE55880 | GEO | 2014/07/24

SECONDARY ACCESSION(S): PRJNA241196

REPOSITORIES: GEO

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Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [miRNA]

Project description:The microRNA changes induced in Primary Mouse Hepatocytes of C57Bl6-mice by Cyclosporin A after treatment for 24h and 48h The study investigated differential microRNA expression in Primary Mouse Hepatocytes following 24 and 48 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/six per solvent. In total 24 arrays .

2014-07-24 | E-GEOD-55880 | biostudies-arrayexpress

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [RNA]

Project description:The transcriptomics changes induced in Primary Mouse Hepatocytes by Cyclosporin A after treatment for 24h and 48h

2014-07-24 | GSE55881 | GEO

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [RNA]

Project description:The transcriptomics changes induced in Primary Mouse Hepatocytes by Cyclosporin A after treatment for 24h and 48h The study investigated differential gene expression in Primary Mouse Hepatocytes mRNA following 24 and 48 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/solvent. In total 24 arrays .

2014-07-24 | E-GEOD-55881 | biostudies-arrayexpress

Expression Profiles of microRNAs of HepG2 cells treated with Cyclosporin A and solvent control

Project description:The microRNA changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h

2015-01-27 | GSE45800 | GEO

Expression Profiles of HepG2 cells treated with Cyclosporin A and solvent control

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h

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Expression Profiles of microRNAs of HepG2 cells treated with Cyclosporin A and solvent control

Project description:The microRNA changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h The study investigated differential microRNA expression in HepG2 cell line following 12, 24, 48 and 72 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/solvent. In total 36 arrays .

2015-01-27 | E-GEOD-45800 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with Cyclosporin A and solvent control

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h The study investigated differential gene expression in HepG2 cell line mRNA following 12, 24, 48 and 72 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/solvent. In total 36 arrays.

2015-01-27 | E-GEOD-45635 | biostudies-arrayexpress

Effects of bGH treatment on rat primary hepatocytes

Project description:Hepatocytes prepared from male livers where culture on matrigel before addition of bGH (50nM). RNA was prepared 24h and 48h later. Keywords: time-course

2005-05-04 | GSE2492 | GEO

Effects of bGH treatment on rat primary hepatocytes

Project description:Hepatocytes prepared from male livers where culture on matrigel before addition of bGH (50nM). RNA was prepared 24h and 48h later.

2010-06-10 | E-GEOD-2492 | biostudies-arrayexpress

Drug-induced hepatotoxicity screening in primary mouse hepatocytes, an Omics approach.

Project description:Drug-induced hepatotoxicity is a leading cause of attrition of candidate drugs in drug development. Therefore new screening methods are necessary which predict these hazards more accurate and earlier in the drug development process. Of all in vitro hepatotoxicity models, primary human hepatocytes are considered as 'the gold standard'. However, the use of these hepatocytes is hindered by their scarcity and major inter-individual variation. These limitations may be overcome with use of primary mouse hepatocytes. Within this context changes in protein expressions in primary mouse hepatocytes, after exposure to cyclosporin A were studied using differential gel electrophoresis. Thereafter, the mRNA expression levels of these deregulated proteins from cyclosporin A-treated cells were analyzed. Cyclosporin A induced ER stress and altered the ER-Golgi transport, which may alter vesicle mediated transport and protein secretion. Moreover are the differentially expressed proteins observed upon challenge by cyclosporin A, associated with cholestatic mechanisms.

2013-04-01 | GSE33742 | GEO

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