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Microarray analysis of a Drosophila dopamine transporter mutant, fumin (fmn)

ABSTRACT: We previously found a short sleeper mutant, fmn, and identified its mutation in the dopamine transporter gene. In an attempt to discover additional sleep related genes in Drosophila, we carried out a microarray analysis comparing mRNA expression in heads of fmn and control flies and found differentially expressed genes. Next, using the pan-neuronal Gal4 driver elav-Gal4 and UAS-RNA interference (RNAi) to knockdown individual genes, we performed a functional screen. We found that knockdown of the NMDA type glutamate receptor channel gene (Nmdar1) reduced sleep.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE56149 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA242556

REPOSITORIES: GEO

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