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Matrine derivative 1b(MASM) offers radioprotection and modulates acute lethal total-body irradiation-induced alterations of gene expression

ABSTRACT: To further investigate the potential molecular basis of the protective effects of MASM on irradiation (6.5Gy) damage, gene expression analysis was conducted on rats liver tissues using microarrays. Pre-treatment with MASM prevented differential expression of 53% (766 genes) of 1445 genes differentially expressed in response to radiation. Pathway enrichment analysis indicated that these genes were mainly involved in a total of 21 pathways, such as metabolic pathways, pathways in cancer, and MAPK signaling pathway.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE56263 | GEO | 2014/03/28

SECONDARY ACCESSION(S): PRJNA242798

REPOSITORIES: GEO

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Matrine derivative 1b(MASM) offers radioprotection and modulates acute lethal total-body irradiation-induced alterations of gene expression

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