Gene expression profiling of cardiac-specific overexpression of TNF-α in Des-/- myocardium

ABSTRACT: Tumor Necrosis Factor-α is greatly implicated in heart pathophysiology, while it is upregulated in the failing myocardium. A major target in TNF-α-induced heart failure is the muscle specific intermediate filament cytoskeleton, comprised by desmin. We analysed the effect of cardiac-specific overexpression of TNF-α in the Des-/- myocardium, which is a known model of dilated cardiomyopathy.

ORGANISM(S): Mus musculus

PROVIDER: GSE56286 | GEO | 2015/05/02

SECONDARY ACCESSION(S): PRJNA242841

REPOSITORIES: GEO