Systems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial

ABSTRACT: In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (15 subjects/arm). Experiments were repeated using primary vaginal epithelial cells from four healthy women.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57025 | GEO | 2015/02/23

SECONDARY ACCESSION(S): PRJNA245233

REPOSITORIES: GEO