Genomics

Dataset Information

33

Role of Fun30 remodelers in retrotransposon regulation


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [Sp20b_M] Affymetrix S. pombe Tiling 1.0FR Array

SUBMITTER: Babett Steglich 

PROVIDER: GSE57069 | GEO | 2016-03-03

SECONDARY ACCESSION(S): PRJNA245377 GSE57067 GSE57068

REPOSITORIES: GEO

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Publications

Regulating retrotransposon activity through the use of alternative transcription start sites.

Persson Jenna J   Steglich Babett B   Smialowska Agata A   Boyd Mette M   Bornholdt Jette J   Andersson Robin R   Schurra Catherine C   Arcangioli Benoit B   Sandelin Albin A   Nielsen Olaf O   Ekwall Karl K  

EMBO reports 20160222 5


Retrotransposons, the ancestors of retroviruses, have the potential for gene disruption and genomic takeover if not kept in check. Paradoxically, although host cells repress these elements by multiple mechanisms, they are transcribed and are even activated under stress conditions. Here, we describe a new mechanism of retrotransposon regulation through transcription start site (TSS) selection by altered nucleosome occupancy. We show that Fun30 chromatin remodelers cooperate to maintain a high lev  ...[more]

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