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Identification of gene expression patterns in lymphoma-prone SJL mice of different ages

ABSTRACT: SJL mice spontaneously develop mature B cell lineage lymphomas. These studies were designed to evaluate significant gene expression differences between spleens of control mice that do not develop lymphomas compared to spleens from SJL mice of differeing ages

ORGANISM(S): Mus musculus

PROVIDER: GSE57150 | GEO | 2015/12/31

SECONDARY ACCESSION(S): PRJNA245786

REPOSITORIES: GEO

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Identification of gene expression patterns in lymphoma-prone SJL mice of different ages

Project description:SJL mice spontaneously develop mature B cell lineage lymphomas. These studies were designed to evaluate significant gene expression differences between spleens of control mice that do not develop lymphomas compared to spleens from SJL mice of differeing ages 22 samples were tested from 4 groups of mice - 10 samples from one group and 4 samples each from the other three groups. One sample per array

2015-12-31 | E-GEOD-57150 | biostudies-arrayexpress

Identification of gene expression patterns in spleen of 564+/- mice of different ages

Project description:564Igi mice homozygous for knockin alleles of 564 IgH and IgK expressed high levels of autoantibodies and exhibited a high incidence of mature B cell lymphomas. This study was designed to evaluate the gene expression profiles of 564Igi mice with different ages.

2017-05-18 | GSE96032 | GEO

ATM deficiency in the absence of T cells promotes the development of NF-kB-dependent B cell lymphomas [Gene Expression]

Project description:Our model removes T cells as targets for lymphomagenesis as well as eliminating T cell-dependent immune surveillance. These mice exclusively develop early onset IgM+ B cell lymphomas that histologically and genetically resemble the activated B cell-like (ABC) subset of human diffuse large B cell lymphomas (DLBCL). This dataset includes the comparison of B-cell lymphomas (tumors) from ATMKO.CD3eKO RNA expression levels with normal spleens from both ATMKO.CD3eKO and ATMWT.CD3eKO non-tumor bearing mice.

2015-07-18 | GSE59576 | GEO

SJL, Balb: Leg and Eye, 10/12 months

Project description:SJL & Balb. Leg and eye; 1 year, 10 months Keywords: time-course

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Mus musculus strain:SJL

Project description:Mus musculus strain:SJL Raw sequence reads

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Colonic tissues from an acute TNBS-induced colitis model in SJL mice.

Project description:Experimental colitis is often used as a model for the inflammatory bowel diseases, ulcerative colitis and Crohn’s disease. Results identify the inflammatory processes during acute colitis in affected tissues from TNBS-treated susceptible 5-7 week old SJL mice. Keywords: Disease state analysis

2008-09-08 | GSE12139 | GEO

Transcriptional profile of the CNS of pups from Zika virus-infected SJL mothers treated with nanoliposomes loaded with AHR antagonist CH223191

Project description:SJL pregnant mice were infected with Zika virus and treated with nanoliposomes loaded with AHR antagonist CH223191 or control nanoliposomes. RNA-Seq analysis was performed in CNS samples from the pups.

2020-04-13 | GSE147094 | GEO

Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Project description:Differential interleukin-10 (IL-10) expression is suspected to contribute to strain specific differences in the course of Theiler's murine encephalomyelitis virus infection in mice. To determine the expression kinetics of IL-10 and related genes, RNA-based next generation sequencing (RNA-seq) was performed with brain cells obtained from infected SJL mice. Methods: 5-week old, female SJL mice were infected with the BeAn strain of TMEV and sacrificed 4, 7 or 14 days post infection (dpi). RNA was isolated from transversal sections of brain tissue at the level of the hippocampus. RNA-seq was performed on an Illumina HiSeq2500 system. Genes involved in Interleukin-10 (IL-10) signalling were analyzed and transcript levels were compared during the course of infection. Results: A significant upregulation of Interleukin-10 (Il10), Interleukin-10 receptor subunit α (ll10rα), Janus kinase 1 (Jak1) and signal transducer and activator of transcription 3 (Stat3) was detected 7 days post infection (dpi) compared to 4 dpi. Same genes showed a significant downregulation at 14 dpi compared to 7 dpi. Suppressor of cytokine signaling 3 (Socs3) was significantly downregulated at 14 dpi compared to 7 dpi. No differences were detected between transcript levels of interleukin-10 receptor subunit β (Il10rβ) and tyrosine kinase 2 (Tyk2). Conclusion: IL-10 pathway gene expression is transiently upregulated following TMEV-infection of SJL-mice.

2018-05-09 | GSE103698 | GEO

Expression data from primary mouse Emu-myc B-cell lymphoma.

Project description:We are interested in genetic programs and mutations which impact on tumor development and sensitivity to anticancer therapies. Utilizing Emu-myc transgenic mice, which spontaneously develop aggressive B-cell lymphomas, we aimed here to study the effects of drug responses in vivo. For that purpose, primary lymphomas from the Emu-myc transgenic mice were transplanted in several immunocompetent recipients and exposed to a single dose Cyclophosphamide (CTX), a standard component of chemotherapeutic regimens used to treat human B-cell lymphomas. Approximately one half of recipient mice are cured with this treatment (Never Relapse Lymphomas, NR), while in other half lymphomas relapse over time (Relapse Prone Lymphomas, RP), allowing us to treat these relapsed mice with progressively shorter durations of remission into full-blown clinical resistance (Resistant Lymphomas, RES). Looking at the differences between NR, RP and RES lymphomas, each in therapy-naive state or after drug challenge, we aimed here to decipher the genetic and biochemical components determining the susceptibility of lymphoma cells to respond to standard chemotherapeutic drugs.

2020-03-19 | GSE134751 | GEO

Gene expression profiles of LN3 T-ALL cells, and tumor-associated and WT thymic dendritic cell subsets

Project description:Thymic lymphomas develop spontaneously in LN3 mice. As for T-ALL in general, ex vivo LN3 lymphoma cells require stromal support to remain viable in culture. We found that primary stromal cells from thymic lymphomas, but not from wild-type thymi, support ex vivo lymphoma survival. By FACS sorting stromal populations, we identified dendritic cells in the tumor microenvironment as the cells capable of supporting lymphoma survival. We used microarrays to analyze the gene expression profiles of T-ALL cells and tumor-associated versus wild-type thymic dendritic cell subsets.

2016-01-29 | GSE54609 | GEO

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