Genomic analysis of low-grade serous ovarian carcinomas [ILOEF]

ABSTRACT: Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted.We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57276 | GEO | 2014/10/01

SECONDARY ACCESSION(S): PRJNA246156

REPOSITORIES: GEO