Novel culture conditions facilitating the induction of naïve pluripotency in human embryonic stem cells

ABSTRACT: We report a novel culture condition inducing naive pluripotency in hESCs in a rapid, robust and reproducible way. These naive hESCs were similar to mESCs exhibiting domed colony morphology, increased single survival, reduced doubling time, upregulation of naive pluripotency-specific genes, unbiased lineage-specific differentiation, hypomethylation, separate clustering profile from parental primed hESCs and were dependent on signalling pathways similar to naive mESCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57318 | GEO | 2015/06/29

SECONDARY ACCESSION(S): PRJNA246240

REPOSITORIES: GEO