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SDF-1 chemokine signaling modulates the apoptotic responses of clathrin-depleted DT40 cells

ABSTRACT: The cell line DKO-S is derived form chicken B-Cell DT40 cells where the clathrin heavy-chain has been placed under the control of a tetracycline-regulatable promoter (Tet-Off). The originally derived cell-line DKO-S underwent apoptosis when clathrin expression was repressed. A cell line, DKO-R, derived from DKO-S cells that was less sensitive to clathrin-depletion. This project explores the differnces in gene expression between DKO-R and DKO-S cells

ORGANISM(S): Gallus gallus

PROVIDER: GSE57328 | GEO | 2014/05/07

SECONDARY ACCESSION(S): PRJNA246282

REPOSITORIES: GEO

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SDF-1 chemokine signaling modulates the apoptotic responses of clathrin-depleted DT40 cells

Project description:The cell line DKO-S is derived form chicken B-Cell DT40 cells where the clathrin heavy-chain has been placed under the control of a tetracycline-regulatable promoter (Tet-Off). The originally derived cell-line DKO-S underwent apoptosis when clathrin expression was repressed. A cell line, DKO-R, derived from DKO-S cells that was less sensitive to clathrin-depletion. This project explores the differnces in gene expression between DKO-R and DKO-S cells Duplicate samples ofDT40, DKO-S or DKO_R cells either with or without treatment with deoxycyclin are compared as is the expression between DKO-R and DKO-S cell lines

2014-05-07 | E-GEOD-57328 | biostudies-arrayexpress

Characterization of gene expression changes in IRF4-deficient DT40 B cells

Project description:The aim of experiment was to study on genome-wide level IRF4 target genes in chicken DT40 B cell line, by comparizon of gene expression profiles of IRF4-deficient DT40 cells with WT IRF4 DT40 cells .

2017-01-01 | GSE56165 | GEO

DT40 genome

Project description:The genome of the DT40 chicken bursal lymphoma cell line

| PRJEB6887 | ENA

Expression data from chicken B cell lymphoma (DT40) cell lines.

2008-10-27 | GSE11597 | GEO

Evaluation of the chicken transcriptome by SAGE of B cell and the DT40 cell line

Project description:These libraries represent total RNA from bursal tissue of 20 day old CB-inbred chicks and the ALV induced bursal cell line DT40 Cre1 cells. Keywords = chicken transcriptome SAGE Bursal cell DT40 Keywords: other

2004-10-06 | GSE1817 | GEO

Effect of auxin (indole-3-acetic acid) on chicken DT40 cells

Project description:DT40 cells and a stable DT 40 cell line expressing OsTIR1 (clone 9) were treated with 500µM IAA for 6 hours. This experiment was conducued to see if auxin would induce a specific sets of genes in animal, like it does for plant cells. We didn't observe a significant difference between the mock control and IAA treatments in both DT40 cells and the stable cells.

2009-10-01 | GSE17523 | GEO

Evaluation of the chicken transcriptome by SAGE of B cell and the DT40 cell line

2004-10-06 | E-GEOD-1817 | biostudies-arrayexpress

Transcription profiling of chicken B cell lymphoma (DT40) cell lines.

Project description:Global gene expression profiling of the avian B-lymphoma DT40 cell line was used as a model to differentiate among Btk KO and Btk KO cells reconstituted with human Btk. Differences in the gene expression pattern showed statistically significant changes between parental DT40 and all the Btk KO cell populations irrespective of whether they are reconstituted or not. These results imply that in the process of generating a knockout cell line, subclones are selected, which have multiple changes in their gene expression pattern (p<0.01). Experiment Overall Design: DT40 cells along with the mutants were grown at various time points in different batches of fetal calf serum with or without any stimulation. All experiments were repeated ten times and then polled together as one sample. In total 28 samples were used RNA extraction and hybridization on Affymetrix microarrays.

2008-11-13 | E-GEOD-11597 | biostudies-arrayexpress

DT40 whole cell proteome (SILAC)

Project description:SILAC quantitative proteomics was used to compare the whole cell proteomes of the differentially SILAC-labelled wild-type and acentrosomal (stil KO) DT40 cell lines.

2019-05-30 | PXD011248 | Pride

Transcriptional Profiles in Bursal B-Lymphoid DT40 Cells Infected with Very Virulent Infectious Bursal Disease Virus

Project description:Infectious bursal disease virus (IBDV) causes a highly contagious, immunosuppressive disease in chickens. The virus mainly infects immature B lymphocytes in the bursa of Fabricius (BF). Chicken B cell line DT40, an avian leukosis virus-induced B cell line, supports very virulent IBDV (vvIBDV) infection in vitro and thereby serves as a good model for investigating the infection and pathogenesis of this virus. However, a transcriptome-wide understanding of the interaction between vvIBDV and B cells has not yet been achieved. This study aimed to employ time-course DNA microarrays to investigate gene expression patterns in DT40 cells after infection with vvIBDV strain LX.

2016-10-01 | GSE71888 | GEO

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