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Idiopathic thrombocytopenic purpura (ITP)

ABSTRACT: CD3+ cells were studied in duplicate from healthy controls, patients with active ITP and ITP in remission. Keywords: repeat sample

ORGANISM(S): Homo sapiens

PROVIDER: GSE574 | GEO | 2003/08/08

SECONDARY ACCESSION(S): PRJNA85347

REPOSITORIES: GEO

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Transcription profiling of pooled human CD3+ cells in duplicate from healthy controls vs. patients with active chronic idiopathic thrombocytopenic purpura (ITP) and ITP in remission.

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2007-09-28 | E-GEOD-574 | biostudies-arrayexpress

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Project description:Whole blood transcriptional profiling of pediatric idiopathic thrombocytopenic purpura (ITP) patients comparing self-limited acute ITP patients with chronic ITP patients or progression-to-chronic ITP patients. Patient samples were collected during 3 different disease states: 8 samples from acute ITP pts (within 6 months of dx, during active disease), 4 samples from progression-to-chronic ITP pts (within 6 months of dx), and 14 samples from chronic ITP (after 6 months of dx).

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [mRNA]

Project description:MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP.

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