Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A role for Tac2, NkB and Nk3 receptor in normal and dysregulated fear memory consolidation

ABSTRACT: Analysis of amygdala RNA expression after auditory fear conditioning in mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE57465 | GEO | 2014/05/09

SECONDARY ACCESSION(S): PRJNA246495

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

A role for Tac2, NkB and Nk3 receptor in normal and dysregulated fear memory consolidation

Project description:Analysis of amygdala RNA expression after auditory fear conditioning in mice. Total RNA from three groups was obtained: 1) Home Cage (HC) 2) 30 minutes after Fear Conditioning (FC) 3) 2 hours after FC.

2014-05-09 | E-GEOD-57465 | biostudies-arrayexpress

miRNA and consolidation of cued fear memory

Project description:miRNA profiling was carried out using the miRCURY LNA™ microRNA Array (6th gen - hsa, mmu & rno) miRNA were profiled in amygdala brain tissue obtained from adult mice 30 mins after auditory fear conditioning and expression levels compared to tissue obtained from Home cage controls Adult male mice were fear conditioned using tone-shock pairings and brains were harvested 30 mins later. The brains of Home Cage controls and Fear Conditioned animals (n = 4/group) were then punched to collect amygdala tissue. miRNA were extracted using the Qiagen miRNeasy Kit, and then shipped to Exiqon. Exiqon performed labeling, hybridization and data analysis after use of the miRCURY LNA™ microRNA Array (6th gen - hsa, mmu & rno). https://www.exiqon.com/ls/Documents/Scientific/miRCURY-LNA-microRNA-Array-6th-gen-hsa-mmu-rno-manual.pdf

2014-09-30 | E-GEOD-59072 | biostudies-arrayexpress

miRNA and consolidation of cued fear memory

2014-09-30 | GSE59072 | GEO

Oprl1 regulation of amygdala-dependent fear in mice and humans with PTSD

Project description:Analysis of amygdala RNA expression 2 hours after auditory fear conditioning in mice with and without previous exposure to acute immobilization stress Total RNA from three groups was obtained: 1) Home Cage (HC) 2) Fear Conditioning (FC) 3) Immobilization (IMO) + FC

2013-04-01 | E-GEOD-44944 | biostudies-arrayexpress

The gastrin-releasing peptide regulates stress-enhanced fear and dopamine signaling

Project description:Fear extinction is an adaptive behavioral process critical for organism’s survival, but deficiency in extinction may lead to PTSD. While the amygdala and its neural circuits are critical for fear extinction, the molecular identity and organizational logic of cell types that lie at the core of these circuits remain unclear. Here we report that mice deficient for amygdala-enriched gastrin-releasing peptide gene (Grp-/-) exhibit enhanced neuronal activity in the basolateral amygdala (BLA) and stronger fear conditioning, as well as deficient extinction in stress-enhanced fear learning (SEFL). rAAV2-retro-based tracing combined with visualization of the GFP knocked in the Grp gene showed that BLA receives several GRPergic conditioned stimulus projections: from the indirect auditory thalamus-to-auditory cortex pathway, medial prefrontal cortex, ventral hippocampus and ventral tegmental area. Transcription of dopamine-related genes was decreased in BLA of Grp-/- mice following SEFL extinction recall, suggesting that the GRP may mediate fear extinction regulation by dopamine.

2021-12-01 | GSE164226 | GEO

Npas4 CUT&Tag in amygdala tissue after discriminative fear conditioning

Project description:Npas4 CUT&Tag dataset, Adult male WT C57BL/6J mice underwent discriminative fear conditioning and immediately injected saline. 90 minutes after fear conditioning, The amygdala tissue was extracted for further experiment. Npas4 CUT&Tag was performed to elucidate possible downstream targets which contributes regulation of fear expression during fear retreival.

2023-07-05 | GSE194069 | GEO

Dorsal hippocampal transcriptome analysis after Auditory Fear Conditioning and pharmacological GR modulation

Project description:Aim: We investigated the role of GR in Auditory Fear Conditioning memory consolidation by application of a pharmacological filter using selective glucocorticoid receptor modulators. Methods: Adult male mice were exposed to Auditory Fear Conditioning training and subsequently injected with 3.0 mg/kg corticosterone, 20 mg/kg CORT108297, 80 mg/kg CORT118335, 40 mg/kg RU486 or vehicle. Dorsal hippocampi were dissected 3 hours after injection and snap-frozen. Total RNA was isolated and send for 100bp paired-end sequencing by BGI.

2023-05-01 | GSE202236 | GEO

Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD

Project description:Analysis of amygdala RNA expression 2 hours after auditory fear expression test in mice with and without previous exposure to acute immobilization stress.

2013-04-01 | GSE44944 | GEO

A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation.

Project description: Not available

| S-EPMC4103970 | biostudies-literature

Cell types in the mouse amygdala and their transcriptional response to fear conditioning

Project description:We performed single-cell RNA-seq of full, microdissected and dissociated mouse amygdala, 2h, 8h or 24h after tone-cued fear conditioning (CFC), and 2h after recall (exposure to CS only, 24h post-CFC), and naive homecage controls.

2023-01-01 | E-MTAB-12096 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data