Gene expression changes initiated by miR-34c in Dicer/Pten double knockout mouse serous epithelial cancer

ABSTRACT: miR-34c inhibits Dicer/Pten double knockout mouse serous epithelial cancer cell proliferation by inducing cell cycle arrest and apoptosis. We found that miR-34c had a more dramatic effect on inhibiting tumor cell viability than let-7b. The action of miR-34c induced tumor cell cycle arrest in G1 phase and apoptosis and was accompanied with the regulation of key genes involved in cell proliferation and cell cycle G1/S transition. miR-34c suppressed the expression of EZH2 and MYBL2, which may transcriptionally and functionally activate CDKN1C.

ORGANISM(S): Mus musculus

PROVIDER: GSE57493 | GEO | 2014/10/03

SECONDARY ACCESSION(S): PRJNA246575

REPOSITORIES: GEO