Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of genomic loci associated with Rhodococcus equi susceptibility in foals

ABSTRACT: aCGH performed to identify copy number variants in Quarter Horses and perform casec-control GWAS

ORGANISM(S): Equus caballus

PROVIDER: GSE57510 | GEO | 2014/05/10

SECONDARY ACCESSION(S): PRJNA246572

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Identification of genomic loci associated with Rhodococcus equi susceptibility in foals

Project description:aCGH performed to identify copy number variants in Quarter Horses and perform casec-control GWAS Two-condition experiment, All samples were compared to a single Quarter Horse reference to identify copy number variants to be used in the CNV GWAS

2014-05-10 | E-GEOD-57510 | biostudies-arrayexpress

Identification of genomic loci associated with Rhodococcus equi susceptibility in foals.

Project description: Not available

| S-EPMC4043894 | biostudies-literature

Genome-wide detection by array CGH of copy number variations among diverse horse breeds

Project description:Investigating genome-wide characteristics of CNVs in 6 horses representing 6 distinct breeds by using the aCGH method and performed GO and KEGG analysis for the CNVs genes.This result is an important complement to the mapping of horse whole-genome CNVs and helpful to study plateau horses’ adaption to the plateau’s environment.

2014-02-26 | GSE52504 | GEO

Genomic imbalances of lung cancer

Project description:The array comparative genomic hybridization (aCGH) was perform to identify regions with genomic imbalance in lung cancer.The aCGH analysis detected a total of 325 regions with genomic imbalance in all 8 lung cancer samples, ranging from focal rearrangements (70 kb–5 Mb) to chromosome-arm alterations with chromosomal segments amplification or deletion. Among these mutations, a total of 115 genomic imbalances were discovered occurring at high frequency varying from 25% to 50%.

2016-11-17 | GSE89927 | GEO

Immunogenicity of an electron beam inactivated Rhodococcus equi vaccine in neonatal foals.

Project description: Not available

| S-EPMC4143214 | biostudies-literature

Integrative genomic analyses revealed colorectal cancer susceptibility genes in risk loci identified in genome-wide association studies

Project description:Genome-wide association studies (GWAS) have identified approximately 50 loci associated with colorectal cancer (CRC) risk. However, the target genes and underlying mechanisms are largely unknown. We conducted a cis-expression quantitative trait loci (cis-eQTL) analysis using data from the Genotype-Tissue Expression (GTEx), The Cancer Genome Atlas (TCGA), and the Colonomics projects. We identified 24 putative target genes for 17 index SNPs at Benjamini-Hochberg adjusted P < 0.05 in at least one of the datasets. By analyzing functional genomic data, our result further indicated that 18 genes (75%) showed evidence of cis-regulation by putative functional SNPs via promoter or enhancer-promoter interactions. We next performed in vitro functional assays for three genes, TMBIM1, AAMP, and CABLES2, and confirmed that they play a vital role in colorectal carcinogenesis via disruption of cell behavior. Furthermore, our results indicate that silencing CABLES2 can promote the PI3K/AKT pathway. Our study reveals new candidate susceptibility genes and provides novel insight into the biological mechanisms for CRC development.

2018-10-23 | GSE121553 | GEO

Genome-wide association study identifies three novel susceptibility loci for systemic mastocytosis

Project description:To identify SNPs predisposing to systemic mastocytosis (SM) we performed a two stage GWAs consisting of two cohorts from the UK and Germany at stage 1 and three cohorts from Spain, Italy and Denmark at stage 2. At both stages, the SM cases were compared with publicly available controls. The control cohorts used were WTCCC and KORA at stage 1 and the Spanish National DNA bank, InChianti and Inter99 at stage 2. The data available are raw intensity files for 480 SM cases that were genotyped at stage 1. Please see our publication (Galata et al 2020) for details regarding QC of the stage 1 samples.

2020-08-03 | E-MTAB-9358 | biostudies-arrayexpress

Development of septic polysynovitis and uveitis in foals experimentally infected with Rhodococcus equi.

Project description: Not available

| S-EPMC5802921 | biostudies-literature

Analysis of Genomic Copy Number Variation in Equine Recurrent Airway Obstruction

Project description:Sixteen severly RAO (Recurrent Airway Obstruction) affected horses were studied. All RAO affected male horses were hybridized with GSM1332974 (Thoroughbred male 1, male reference), and the female horses were with GSM1332975 (Thoroughbred female 2, female reference). Finally results are compared with GSE55266 and two other control horses (SPA-H1-3 and SPA-H1-5) and relatively novel RAO CNVs were reported.

2016-03-07 | GSE63033 | GEO

TRPM2 SNP genotype previously associated with susceptibility to Rhodococcus equi pneumonia in Quarter Horse foals displays differential gene expression identified using RNA-Seq.

Project description: Not available

| S-EPMC5139010 | biostudies-literature