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Expression analysis of the effects of methyl-donor deficient diet on male mice (part 2)

ABSTRACT: BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and mated with control females. Tissue samples were taken from eigth-week old male offspring of control and treated males. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

ORGANISM(S): Mus musculus

PROVIDER: GSE57522 | GEO | 2014/05/29

SECONDARY ACCESSION(S): PRJNA246589

REPOSITORIES: GEO

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Expression analysis of the effects of methyl-donor deficient diet on male mice (part 3)

Project description:CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0 and 2 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

2014-05-29 | GSE57523 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 1)

Project description:BALB/c and CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in spleen of mice sacrificed immediatelly after the end of dietary restrictions is not significatly altered.

2014-05-29 | GSE57521 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0, 2 and 6 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

2012-12-13 | GSE42744 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 2)

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and mated with control females. Tissue samples were taken from eigth-week old male offspring of control and treated males. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered. A ten 12x135K chip study using total RNA extracted from kidney and liver of control and treated BALB/c male mice. The expression of 42,575 genes was measured with two-fold technical redundancy.

2014-05-29 | E-GEOD-57522 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice

2012-12-13 | E-GEOD-42744 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 1)

2014-05-29 | E-GEOD-57521 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 3)

2014-05-29 | E-GEOD-57523 | biostudies-arrayexpress

Comparative gene-expression analysis on the first-generation offspring of irradiated male and female mice

2013-01-29 | GSE42933 | GEO

Comparative gene-expression analysis on the first-generation offspring of irradiated male and female mice

Project description:Invstigation of whole genome gene expression level changes in kidney of the male offspring of BALB/c male and female mice exposed to 1 Gy of acute X-rays The design of this study is further described in Abouzeid Ali, H. E., R. C. Barber, and Y. E. Dubrova. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732(1): 21-25. (PMID: 22289278). A six 12x135K chip study using total RNA extracted from kidney of control and treated BALB/c male mice. The expression of 42,575 genes was measured with at least two-fold technical redundancy.

2013-01-29 | E-GEOD-42933 | biostudies-arrayexpress

Excess folic acid supplementation increases adiposity and impacts insulin sensitivity in female mice during pregnancy and has sex-specific effects on fetal offspring

Project description:We determined the effects of excess folic acid supplementation (5x recommendation) on maternal and fetal offspring metabolic health. Using a mouse (female C57BL/6J) model of gestational dibetes (GDM; 45% kcal fat diet) and control mice (10% kcal diet) we show that folic acid supplementation increased weight gain and fat mass in both GDM and control mice but improved insulin sensitivity in GDM mice and worsened insulin sensitivity in control mice. We found no unmetabolized folic acid in liver from supplemented mice suggesting the metabolic effects of folic acid supplementation may not be due to unmetabolized folic acid. Male fetal (gestational day 18.5) offspring from folic acid supplemented dams (GDM and control) had greater beta cell mass and density than those from unsupplemented dams; this was not observed in female offspring. Differential sex-specific hepatic gene expression profiles were observed in the offspring from supplemented dams but this differed between GDM and controls. Our findings suggest that folic acid supplementation affects insulin sensitivity in female mice, but is dependent on their metabolic phenotype, and has sex-specific effects on offspring pancreas and liver.

2023-09-29 | GSE237149 | GEO

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